| http://purl.uniprot.org/citations/9813230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9813230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9813230 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is regulated by phosphorylation, ubiquitination, and degradation of its inhibitory factor IkappaB. Very recently, two closely related serine/threonine kinases have been identified as IkappaB kinases which are essential for IkappaB phosphorylation and NF-kappaB activation. Here, we isolated the full-length human cDNA clones encoding these two IkappaB kinases, IKK-alpha and IKK-beta. Both polypeptides contain a conserved amino-terminal kinase domain, a leucine zipper motif and a helix-loop-helix domain at their carboxyl terminus. We showed that IKK-alpha and IKK-beta were coexpressed in most human adult tissues as well as in different developmental stages of mouse embryos, suggesting that they may cooperate in the cells. The IKK-alpha and IKK-beta genes are distinct but evolutionarily conserved. Moreover, the IKK-alpha gene locus was mapped to human chromosome 10q24, whereas the IKK-beta gene locus was localized to human chromosome 8p11.2. These results indicated that both genes are not clustered on the same chromosome; nevertheless, both genes may be still regulated similarly during development and in adult tissues."xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(98)00462-4"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(98)00462-4"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/author | "Wang Y.-P."xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/author | "Wang Y.-P."xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/author | "Hu M.C.-T."xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/author | "Hu M.C.-T."xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/pages | "31-40"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/pages | "31-40"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/title | "IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes."xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/title | "IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes."xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/volume | "222"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://purl.uniprot.org/core/volume | "222"xsd:string |
| http://purl.uniprot.org/citations/9813230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9813230 |
| http://purl.uniprot.org/citations/9813230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9813230 |
| http://purl.uniprot.org/citations/9813230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9813230 |
| http://purl.uniprot.org/citations/9813230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9813230 |
| http://purl.uniprot.org/uniprot/O14920 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9813230 |
| http://purl.uniprot.org/uniprot/O15111 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9813230 |