| http://purl.uniprot.org/citations/9820540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9820540 | http://www.w3.org/2000/01/rdf-schema#comment | "The recently described IL-1R accessory protein (IL-1R AcP) interacts with IL-1beta and the IL-1 type-IR (IL-1RI), but an essential requirement for IL-1R AcP in IL-1 signaling in vitro has not been established and its role in vivo has not been examined. In this study, IL-1R AcP-deficient mice and fibroblasts were produced and characterized. All IL-1 agonists bound to IL-1R AcP-deficient cells through the type I IL-1R, but failed to activate gene expression through either the nuclear factor-kappaB or AP-1-dependent signaling pathways. Absence of IL-1R AcP differentially affected the affinity for IL-1 ligands. IL-1R AcP-deficient fibroblasts bound murine IL-1alpha and human IL-1R antagonist protein (IL-1Ra) with only moderately reduced affinity when compared with wild-type cells, whereas murine IL-1beta affinity was reduced by 70-fold. IL-1 also failed to produce a biologic response in vivo in IL-1R AcP-deficient mice. These data demonstrate that a type I IL-1R/IL-1R AcP complex is required for signaling by all IL-1 agonists and for high affinity binding by IL-1beta. Finally, IL-1R AcP is an essential signal transducing component of the functional IL-1R and should represent a novel target for blocking IL-1 function in human disease."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "Labow M.A."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "Nunes P."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "Chizzonite R.A."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "Ju G."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "Kwee L."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "Cullinan E.B."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "Shuster D.J."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/author | "McIntyre K.W."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/pages | "5614-5620"xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/title | "IL-1 receptor accessory protein is an essential component of the IL-1 receptor."xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/9820540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9820540 |
| http://purl.uniprot.org/citations/9820540 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9820540 |
| http://purl.uniprot.org/uniprot/#_E9Q6I2-mappedCitation-9820540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9820540 |
| http://purl.uniprot.org/uniprot/#_G3UY13-mappedCitation-9820540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9820540 |
| http://purl.uniprot.org/uniprot/#_G3XA78-mappedCitation-9820540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9820540 |
| http://purl.uniprot.org/uniprot/#_Q3UEL3-mappedCitation-9820540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9820540 |
| http://purl.uniprot.org/uniprot/#_Q3V2X3-mappedCitation-9820540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9820540 |
| http://purl.uniprot.org/uniprot/#_Q61730-mappedCitation-9820540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9820540 |
| http://purl.uniprot.org/uniprot/Q3UEL3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9820540 |
| http://purl.uniprot.org/uniprot/Q3V2X3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9820540 |