| http://purl.uniprot.org/citations/9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9822605 | http://www.w3.org/2000/01/rdf-schema#comment | "We show here that Vav-2, a member of the Vav family of oncoproteins, acts as a guanosine nucleotide exchange factor (GEF) for RhoG and RhoA-like GTPases in a phosphotyrosine-dependent manner. Moreover, we show that Vav-2 oncogenic activation correlates with the acquisition of phosphorylation-independent exchange activity. In vivo, wild-type Vav-2 is activated oncogenically by tyrosine kinases, an effect enhanced further by co-expression of RhoA. Likewise, the Vav-2 oncoprotein synergizes with RhoA and RhoB proteins in cellular transformation. Transient transfection assays in NIH-3T3 cells show that phosphorylated wild-type Vav-2 and the Vav-2 oncoprotein induce cytoskeletal changes resembling those observed by the activation of the RhoG pathway. In contrast, the constitutive expression of the Vav-2 oncoprotein in rodent fibroblasts leads to major alterations in cell morphology and to highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled. These results identify a regulated GEF for the RhoA subfamily, provide a biochemical explanation for vav family oncogenicity, and establish a new signaling model in which specific Vav-like proteins couple tyrosine kinase signals with the activation of distinct subsets of the Rho/Rac family of GTPases."xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.22.6608"xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/author | "Rosa J.L."xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/author | "Bustelo X.R."xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/author | "Schuebel K.E."xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/author | "Movilla N."xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/pages | "6608-6621"xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/title | "Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2."xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9822605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9822605 |
| http://purl.uniprot.org/citations/9822605 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9822605 |
| http://purl.uniprot.org/uniprot/#_P52735-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_P61586-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_Q14155-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_A1L390-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_O15085-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_P62745-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_Q12802-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_Q12979-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_Q13009-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_O75962-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |
| http://purl.uniprot.org/uniprot/#_P15498-mappedCitation-9822605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9822605 |