| http://purl.uniprot.org/citations/9823896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9823896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9823896 | http://www.w3.org/2000/01/rdf-schema#comment | "Organisms in many phyla determine sexual fate by distinguishing one X chromosome from two. Here we use the model organism Caenorhabditis elegans to dissect such an X-chromosome-counting mechanism in molecular detail. In this nematode, several genes on the X chromosome called X signal elements communicate X-chromosome dose by controlling the activity of the sex-determination gene xol-1. xol-1 specifies male (XO) fate when active and hermaphrodite (XX) fate when inactive. The only X signal element described so far represses xol-1 post-transcriptionally, but xol-1 is repressed in XX animals by transcriptional and post-transcriptional mechanisms. Here we identify a nuclear-hormone-receptor homologue, SEX-1, that regulates the transcription of xol-1. We show that sex-1 is vital to X-chromosome counting: changing sex-1 gene dose in XX or XO embryos causes sexual transformation and death from inadequate dosage compensation (the hermaphrodite-specific process that equalizes X-gene expression between the sexes). The SEX-1 protein acts directly on xol-1, associating with its promoter in vivo and repressing xol-1 transcription in XX embryos. Thus, xol-1 is the direct molecular target of the primary sex-determination signal, and the dose of a nuclear hormone receptor helps to communicate X-chromosome number to determine nematode sex."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.org/dc/terms/identifier | "doi:10.1038/24164"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.org/dc/terms/identifier | "doi:10.1038/24164"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/author | "Meyer B.J."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/author | "Meyer B.J."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/author | "Carmi I."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/author | "Carmi I."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/author | "Kopczynski J.B."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/author | "Kopczynski J.B."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/pages | "168-173"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/pages | "168-173"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/title | "The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/title | "The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex."xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/volume | "396"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://purl.uniprot.org/core/volume | "396"xsd:string |
| http://purl.uniprot.org/citations/9823896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9823896 |
| http://purl.uniprot.org/citations/9823896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9823896 |
| http://purl.uniprot.org/citations/9823896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9823896 |
| http://purl.uniprot.org/citations/9823896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9823896 |