| http://purl.uniprot.org/citations/9837724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9837724 | http://www.w3.org/2000/01/rdf-schema#comment | "The human Rad52 protein stimulates joint molecule formation by hRad51, a homologue of Escherichia coli RecA protein. Electron microscopic analysis of hRad52 shows that it self-associates to form ring structures with a diameter of approximately 10 nm. Each ring contains a hole at its centre. hRad52 binds to single and double-stranded DNA. In the ssDNA-hRad52 complexes, hRad52 was distributed along the length of the DNA, which exhibited a characteristic "beads on a string" appearance. At higher concentrations of hRad52, "super-rings" (approximately 30 nm) were observed and the ssDNA was collapsed upon itself. In contrast, in dsDNA-hRad52 complexes, some regions of the DNA remained protein-free while others, containing hRad52, interacted to form large protein-DNA networks. Saturating concentrations of hRad51 displaced hRad52 from ssDNA, whereas dsDNA-Rad52 complexes (networks) were more resistant to hRad51 invasion and nucleoprotein filament formation. When Rad52-Rad51-DNA complexes were probed with gold-conjugated hRad52 antibodies, the presence of globular hRad52 structures within the Rad51 nucleoprotein filament was observed. These data provide the first direct visualisation of protein-DNA complexes formed by the human Rad51 and Rad52 recombination/repair proteins."xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1998.2203"xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/author | "Stasiak A."xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/author | "Hajibagheri N.M."xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/author | "Van Dyck E."xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/pages | "1027-1038"xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/title | "Visualisation of human rad52 protein and its complexes with hRad51 and DNA."xsd:string |
| http://purl.uniprot.org/citations/9837724 | http://purl.uniprot.org/core/volume | "284"xsd:string |
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