| http://purl.uniprot.org/citations/9837948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9837948 | http://www.w3.org/2000/01/rdf-schema#comment | "Pex5p is the receptor for the peroxisomal targeting signal 1 (PTS1) that consists of a C-terminal tripeptide (consensus (S/A/C)(K/R/H)(L/M)). Hexadecapeptides recognized by Pex5p from Homo sapiens and Saccharomyces cerevisiae were identified by screening a two-hybrid peptide library, and the targeting ability of the peptides was demonstrated using the green fluorescent protein as reporter. The PTS1 receptors recognized in a species-specific manner a broad range of C-terminal tripeptides, and these are reported herein. In addition, residues upstream of the tripeptide influenced the strength of the interaction in the two-hybrid system as well as in an in vitro competition assay. In peptides interacting with the human protein, hydrophobic residues were found with high frequency especially at positions -2 and -5, whereas peptides interacting with S. cerevisiae Pex5p were more hydrophilic and frequently contained arginine at position -2. In instances where the terminal tripeptide deviated from the consensus, upstream residues exerted a greater influence on the ability of the hexadecapeptides to bind Pex5p."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.50.33635"xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/author | "Berger J."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/author | "Fransen M."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/author | "Hartig A."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/author | "Brocard C."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/author | "Van Veldhoven P."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/author | "Lametschwandtner G."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/pages | "33635-33643"xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/title | "The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it."xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9837948 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9837948 |
| http://purl.uniprot.org/citations/9837948 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9837948 |
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