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http://purl.uniprot.org/citations/9838107http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9838107http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9838107http://www.w3.org/2000/01/rdf-schema#comment"Pineal melatonin synthesis (serotonin --> N-acetylserotonin --> melatonin) is severely compromised in most inbred strains of mice, in many cases because serotonin is not acetylated by serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT). We have found that in the C57BL/6J strain, AANAT mRNA encodes a severely truncated AANAT protein, because a pseudo-exon containing a stop codon is spliced in. This is the first identification of a natural mutation which knocks down melatonin synthesis. The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.org/dc/terms/identifier"doi:10.1016/s0169-328x(98)00273-3"xsd:string
http://purl.uniprot.org/citations/9838107http://purl.org/dc/terms/identifier"doi:10.1016/s0169-328x(98)00273-3"xsd:string
http://purl.uniprot.org/citations/9838107http://purl.org/dc/terms/identifier"doi:10.1016/S0169-328X(98)00273-3"xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Gastel J.A."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Gastel J.A."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Klein D.C."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Klein D.C."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Roseboom P.H."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Roseboom P.H."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Popescu N.C."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Popescu N.C."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Zimonjic D.B."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Zimonjic D.B."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Rodriguez I.R."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Rodriguez I.R."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Namboodiri M.A.A."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/author"Namboodiri M.A.A."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/name"Brain Res. Mol. Brain Res."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/name"Brain Res. Mol. Brain Res."xsd:string
http://purl.uniprot.org/citations/9838107http://purl.uniprot.org/core/pages"189-197"xsd:string