| http://purl.uniprot.org/citations/9841920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9841920 | http://www.w3.org/2000/01/rdf-schema#comment | "We have analyzed the immune system in Stat5-deficient mice. Although Stat5a-/-splenocytes have a partial defect in anti-CD3-induced proliferation that can be overcome by high dose interleukin (IL)-2, we now demonstrate that defective proliferation in Stat5b-/-splenocytes cannot be corrected by this treatment. Interestingly, this finding may be at least partially explained by diminished expression of the IL-2 receptor beta chain (IL-2Rbeta), which is a component of the receptors for both IL-2 and IL-15, although other defects may also exist. Similar to the defect in proliferation in activated splenocytes, freshly isolated splenocytes from Stat5b-/-mice exhibited greatly diminished proliferation in response to IL-2 and IL-15. This results from both a decrease in the number and responsiveness of natural killer (NK) cells. Corresponding to the diminished proliferation, basal as well as IL-2- and IL-15-mediated boosting of NK cytolytic activity was also greatly diminished. These data indicate an essential nonredundant role for Stat5b for potent NK cell-mediated proliferation and cytolytic activity."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.188.11.2067"xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/author | "Imada K."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/author | "Davey H.W."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/author | "Leonard W.J."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/author | "Bloom E.T."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/author | "Udy G.B."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/author | "Horvath-Arcidiacono J.A."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/pages | "2067-2074"xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/title | "Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity."xsd:string |
| http://purl.uniprot.org/citations/9841920 | http://purl.uniprot.org/core/volume | "188"xsd:string |
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