| http://purl.uniprot.org/citations/9843499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9843499 | http://www.w3.org/2000/01/rdf-schema#comment | "Rac is a Rho-family small GTPase that induces the formation of membrane ruffles. However, it is poorly understood how Rac-induced reorganization of the actin cytoskeleton, which is essential for ruffle formation, is regulated. Here we identify a novel Wiskott-Aldrich syndrome protein (WASP)-family protein, WASP family Verprolin-homologous protein (WAVE), as a regulator of actin reorganization downstream of Rac. Ectopically expressed WAVE induces the formation of actin filament clusters that overlap with the expressed WAVE itself. In this actin clustering, profilin, a monomeric actin-binding protein that has been suggested to be involved in actin polymerization, was shown to be essential. The expression of a dominant-active Rac mutant induces the translocation of endogenous WAVE from the cytosol to membrane ruffling areas. Furthermore, the co-expression of a deltaVPH WAVE mutant that cannot induce actin reorganization specifically suppresses the ruffle formation induced by Rac, but has no effect on Cdc42-induced actin-microspike formation, a phenomenon that is also known to be dependent on rapid actin reorganization. The deltaVPH WAVE also suppresses membrane-ruffling formation induced by platelet-derived growth factor in Swiss 3T3 cells. Taken together, we conclude that WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for membrane ruffling."xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.23.6932"xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/author | "Miki H."xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/author | "Suetsugu S."xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/pages | "6932-6941"xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/title | "WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac."xsd:string |
| http://purl.uniprot.org/citations/9843499 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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| http://purl.uniprot.org/citations/9843499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9843499 |
| http://purl.uniprot.org/uniprot/Q92558#attribution-ABD0DFF03AF55E28B9736EA43A378825 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9843499 |
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| http://purl.uniprot.org/uniprot/#_A1L390-mappedCitation-9843499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9843499 |
| http://purl.uniprot.org/uniprot/#_A4D1P6-mappedCitation-9843499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9843499 |
| http://purl.uniprot.org/uniprot/#_A6NGB9-mappedCitation-9843499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9843499 |
| http://purl.uniprot.org/uniprot/#_P19878-mappedCitation-9843499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9843499 |
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| http://purl.uniprot.org/uniprot/#_P42684-mappedCitation-9843499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9843499 |