| http://purl.uniprot.org/citations/9853749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9853749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9853749 | http://www.w3.org/2000/01/rdf-schema#comment | "Specific patterns of neuronal firing induce changes in synaptic strength that may contribute to learning and memory. If the postsynaptic NMDA (N-methyl-D-aspartate) receptors are blocked, long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission and the learning of spatial information are prevented. The NMDA receptor can bind a protein known as postsynaptic density-95 (PSD-95), which may regulate the localization of and/or signalling by the receptor. In mutant mice lacking PSD-95, the frequency function of NMDA-dependent LTP and LTD is shifted to produce strikingly enhanced LTP at different frequencies of synaptic stimulation. In keeping with neural-network models that incorporate bidirectional learning rules, this frequency shift is accompanied by severely impaired spatial learning. Synaptic NMDA-receptor currents, subunit expression, localization and synaptic morphology are all unaffected in the mutant mice. PSD-95 thus appears to be important in coupling the NMDA receptor to pathways that control bidirectional synaptic plasticity and learning."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.org/dc/terms/identifier | "doi:10.1038/24790"xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.org/dc/terms/identifier | "doi:10.1038/24790"xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Grant S.G.N."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Grant S.G.N."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Webster L.C."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Webster L.C."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Migaud M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Migaud M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "O'Dell T.J."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "O'Dell T.J."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Charlesworth P."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Charlesworth P."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Dempster M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Dempster M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Makhinson M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Makhinson M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Morris R.G.M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Morris R.G.M."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Morrison J.H."xsd:string |
| http://purl.uniprot.org/citations/9853749 | http://purl.uniprot.org/core/author | "Morrison J.H."xsd:string |