| http://purl.uniprot.org/citations/9857183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9857183 | http://www.w3.org/2000/01/rdf-schema#comment | "The ectodomains of many proteins located at the cell surface are shed upon cell stimulation. One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored form which is converted to a soluble form upon cell stimulation with TPA, an activator of protein kinase C (PKC). We show that PKCdelta binds in vivo and in vitro to the cytoplasmic domain of MDC9/meltrin-gamma/ADAM9, a member of the metalloprotease-disintegrin family. Furthermore, the presence of constitutively active PKCdelta or MDC9 results in the shedding of the ectodomain of proHB-EGF, whereas MDC9 mutants lacking the metalloprotease domain, as well as kinase-negative PKCdelta, suppress the TPA-induced shedding of the ectodomain. These results suggest that MDC9 and PKCdelta are involved in the stimulus-coupled shedding of the proHB-EGF ectodomain."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.24.7260"xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Izumi Y."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Hirata M."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Tamai Y."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Mekada E."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Hasuwa H."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Kurisaki T."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Iwamoto R."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Miyado K."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Umata T."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/author | "Sehara-Fujisawa A."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/pages | "7260-7272"xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/title | "A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor."xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9857183 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9857183 |
| http://purl.uniprot.org/citations/9857183 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9857183 |
| http://purl.uniprot.org/uniprot/Q61072#attribution-6CB7E51B5231370940F095E7A8AFFACA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9857183 |
| http://purl.uniprot.org/uniprot/Q61072#attribution-BB267A457A45AB3B8FB0F74E64448711 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9857183 |
| http://purl.uniprot.org/uniprot/Q91VJ2#attribution-BB267A457A45AB3B8FB0F74E64448711 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9857183 |
| http://purl.uniprot.org/uniprot/Q06186#attribution-6CB7E51B5231370940F095E7A8AFFACA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9857183 |