| http://purl.uniprot.org/citations/9858518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9858518 | http://www.w3.org/2000/01/rdf-schema#comment | "A system to innocuously visualize T cell lineage commitment is described. Using a "knock-in" approach, we have generated mice expressing a beta-galactosidase reporter in place of CD4; expression of beta-galactosidase in these animals appears to be an accurate and early indicator of CD4 gene transcription. We have exploited this knock-in line to trace CD4/CD8 lineage commitment in the thymus, avoiding important pitfalls of past experimental approaches. Our results argue in favor of a selective model of thymocyte commitment, demonstrating a fundamentally symmetrical process: engagement of either class of major histocompatibility complex (MHC) molecule by a differentiating CD4(+)CD8(+) cell can give rise to T cell antigen receptor (TCR)hi thymocytes of either lineage. Key findings include (a) direct demonstration of a substantial number of CD4-committed, receptor/coreceptor-mismatched cells in MHC class II-deficient mice, a critical prediction of the selective model; (b) highly efficient rescue of such "mismatched" intermediates by forced expression of CD8 in a TCR transgenic line, and an explanation of why previous experiments of this nature were less successful-a major past criticism of the selective model; (c) direct demonstration of an analogous, though smaller, population of CD8-committed mismatched intermediates in class I-deficient animals. Finally, we found no evidence of a CD4 default pathway."xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.188.12.2321"xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/author | "Dierich A."xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/author | "Chan S."xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/author | "Benoist C."xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/author | "Mathis D."xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/author | "Correia-Neves M."xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/pages | "2321-2333"xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/title | "Visualization of CD4/CD8 T cell commitment."xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/9858518 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9858518 |
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| http://purl.uniprot.org/uniprot/#_P06345-mappedCitation-9858518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9858518 |
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