| http://purl.uniprot.org/citations/9859997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9859997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9859997 | http://www.w3.org/2000/01/rdf-schema#comment | "Modification of histones, DNA-binding proteins found in chromatin, by addition of acetyl groups occurs to a greater degree when the histones are associated with transcriptionally active DNA. A breakthrough in understanding how this acetylation is mediated was the discovery that various transcriptional co-activator proteins have intrinsic histone acetyltransferase activity (for example, Gcn5p, PCAF, TAF(II)250 and p300/CBP. These acetyltransferases also modify certain transcription factors (TFIIEbeta, TFIIF, EKLF and p53). GATA-1 is an important transcription factor in the haematopoietic lineage and is essential for terminal differentiation of erythrocytes and megakaryocytes. It is associated in vivo with the acetyltransferase p300/CBP. Here we report that GATA-1 is acetylated in vitro by p300. This significantly increases the amount of GATA-1 bound to DNA and alters the mobility of GATA-1-DNA complexes, suggestive of a conformational change in GATA-1. GATA-1 is also acetylated in vivo and acetylation directly stimulates GATA-1-dependent transcription. Mutagenesis of important acetylated residues shows that there is a relationship between the acetylation and in vivo function of GATA-1. We propose that acetylation of transcription factors can alter interactions between these factors and DNA and among different transcription factors, and is an integral part of transcription and differentiation processes."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.org/dc/terms/identifier | "doi:10.1038/25166"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.org/dc/terms/identifier | "doi:10.1038/25166"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Nakatani Y."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Nakatani Y."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Ogryzko V."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Ogryzko V."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Byfield P."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Byfield P."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Boyes J."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/author | "Boyes J."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/pages | "594-598"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/pages | "594-598"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/title | "Regulation of activity of the transcription factor GATA-1 by acetylation."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/title | "Regulation of activity of the transcription factor GATA-1 by acetylation."xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/volume | "396"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://purl.uniprot.org/core/volume | "396"xsd:string |
| http://purl.uniprot.org/citations/9859997 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9859997 |
| http://purl.uniprot.org/citations/9859997 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9859997 |