| http://purl.uniprot.org/citations/9860978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9860978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9860978 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously isolated 25 temperature-sensitive gsp1 alleles of Saccharomyces cerevisiae Ran homologue, each of which possesses amino acid changes that differ from each other. We report here isolation of three multicopy suppressors-PDE2, NTF2, and a gene designated MOG1-all of which rescued a growth defect of these gsp1 strains. The gsp1 suppression occurred even in the absence of GSP2, another S. cerevisiae GSP1-like gene. Previously, NTF2 was reported to suppress gsp1 but not PDE2. Mog1p, with a calculated molecular mass of 24 kDa, was found to be encoded by the yeast ORF YJR074W. Both MOG1 and NTF2 suppressed a series of gsp1 alleles with similar efficiency, and both suppressed gsp1 even with a single gene dose. Consistent with the high efficiency of gsp1 suppression, Mog1p directly bound to GTP, but not to GDP-Gsp1p. The disruption of MOG1 made yeast temperature-sensitive for growth. Deltamog1, which was suppressed by overexpression of NTF2, was found to have a defect in both classic and nonclassic nuclear localization signal-dependent nuclear-protein imports, but not in mRNA export. Thus, Mog1p, which was localized in the nucleus, is a Gsp1p-binding protein involved in nuclear-protein import and that functionally interacts with Ntf2p. Furthermore, the finding that PDE2 suppressed both gsp1 and rna1-1 indicates that the Ran GTPase cycle is regulated by the Ras-cAMP pathway."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.26.15388"xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.26.15388"xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/author | "Oki M."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/author | "Oki M."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/author | "Nishimoto T."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/author | "Nishimoto T."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/pages | "15388-15393"xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/pages | "15388-15393"xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/title | "A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/title | "A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue."xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9860978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9860978 |
| http://purl.uniprot.org/citations/9860978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9860978 |
| http://purl.uniprot.org/citations/9860978 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9860978 |
| http://purl.uniprot.org/citations/9860978 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9860978 |
| http://purl.uniprot.org/uniprot/P47123 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9860978 |
| http://purl.uniprot.org/uniprot/P47123#attribution-6B1375F0A2AE1826DEE44B040FF2CA92 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9860978 |