| http://purl.uniprot.org/citations/9861014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9861014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9861014 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormalities of fatty acid metabolism are recognized to play a significant role in human disease, but the mechanisms remain poorly understood. Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step in mitochondrial fatty acid oxidation (FAO). We produced a mouse model of LCAD deficiency with severely impaired FAO. Matings between LCAD +/-mice yielded an abnormally low number of LCAD +/- and -/-offspring, indicating frequent gestational loss. LCAD -/-mice that reached birth appeared normal, but had severely reduced fasting tolerance with hepatic and cardiac lipidosis, hypoglycemia, elevated serum free fatty acids, and nonketotic dicarboxylic aciduria. Approximately 10% of adult LCAD -/-males developed cardiomyopathy, and sudden death was observed in 4 of 75 LCAD -/-mice. These results demonstrate the crucial roles of mitochondrial FAO and LCAD in vivo."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.26.15592"xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.26.15592"xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Millington D.S."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Millington D.S."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Tian L."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Tian L."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Brix A.E."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Brix A.E."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Hamm D.A."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Hamm D.A."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Kurtz D.M."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Kurtz D.M."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Lindsey J.R."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Lindsey J.R."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "O'Brien W.E."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "O'Brien W.E."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Pinkert C.A."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Pinkert C.A."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Rhead W.J."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Rhead W.J."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Rinaldo P."xsd:string |
| http://purl.uniprot.org/citations/9861014 | http://purl.uniprot.org/core/author | "Rinaldo P."xsd:string |