| http://purl.uniprot.org/citations/9865498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9865498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9865498 | http://www.w3.org/2000/01/rdf-schema#comment | "IFN-tau (IFN-tau) constitutes a new class of type I IFN which is not virus-inducible, unlike IFN-alpha and IFN-beta, but is constitutively produced by the trophectoderm of the ruminant conceptus during a very short period in early pregnancy. It plays a pivotal role in the mechanisms of maternal recognition of pregnancy in ruminants and it displays high antiviral and antiproliferative activities across species with a prominent lack of cytotoxicity at high concentrations in vitro in cell culture and possibly in vivo. It exhibits high antiretroviral activity against HIV and exhibits immunosuppressive activity in a multiple sclerosis model and reduces embryo and fetal mortality by stimulation of IL-10 production. In this review all the biochemical and para-hormonal properties of this novel IFN-tau are described in detail: structural characteristics of proteins and genes, trophoblast expression, regulation of its expression, structure of its gene promoter, its absence in human species and in non-ruminant animals, the evolution of the IFN-tau genes, its structure-function relationships with its three-dimensional structure, structural localization of biological activities, its lack of cytotoxicity and its receptor. Surprisingly, for an IFN, IFN-tau is also a pregnancy-embryonic signal with paracrine antiluteolytic activity. In order to maintain luteal progesterone secretion, IFN-tau inhibits PGF-2alpha pulsatile secretion and oxytocin uterine receptivity in early pregnancy. It is believed to suppress pulsatile release of endometrial PGF-2alpha by preventing oxytocin and estrogen receptor expression. Additionally, it directly regulates prostaglandin metabolism and possibly the PGE:PGF-2alpha ratio."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0300-9084(99)80029-7"xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0300-9084(99)80029-7"xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Charlier M.A."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Charlier M.A."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Charpigny S.Y."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Charpigny S.Y."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Chene N.M."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Chene N.M."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Guillomot M.W."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Guillomot M.W."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Huynh L.P."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Huynh L.P."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "L'Haridon R.M."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "L'Haridon R.M."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Martal J.L."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Martal J.L."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Reinaud P.B."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/author | "Reinaud P.B."xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |
| http://purl.uniprot.org/citations/9865498 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |