| http://purl.uniprot.org/citations/9867817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9867817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9867817 | http://www.w3.org/2000/01/rdf-schema#comment | "In a genetic screen aimed at the identification of trans-acting factors involved in mRNA 3'-end processing of budding yeast, we have previously isolated two temperature-sensitive mutants with an apparent defect in the 3'-end formation of a plasmid-derived pre-mRNA. Surprisingly, both mutants were rescued by the essential gene ESS1/PTF1 that encoded a putative peptidylprolyl-cis/trans-isomerase (PPIase) (Hani, J., Stumpf, G., and Domdey, H. (1995) FEBS Lett. 365, 198-202). Such enzymes, which catalyze the cis/trans-interconversion of peptide bonds N-terminal of prolines, are suggested to play a role in protein folding or trafficking. Here we report that Ptf1p shows PPIase activity in vitro, displaying an unusual substrate specificity for peptides with phosphorylated serine and threonine residues preceding proline. Both mutations were found to result in amino acid substitutions of highly conserved residues within the PPIase domain, causing a marked decrease in PPIase activity of the mutant enzymes. Our results are suggestive of a so far unknown involvement of a PPIase in mRNA 3'-end formation in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.1.108"xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.1.108"xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Fischer G."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Fischer G."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Domdey H."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Domdey H."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Hani J."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Hani J."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Bernhardt A."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Bernhardt A."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Wiebauer K."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Wiebauer K."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Rahfeld J.-U."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Rahfeld J.-U."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Schelbert B."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/author | "Schelbert B."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/pages | "108-116"xsd:string |
| http://purl.uniprot.org/citations/9867817 | http://purl.uniprot.org/core/pages | "108-116"xsd:string |