| http://purl.uniprot.org/citations/9868772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9868772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9868772 | http://www.w3.org/2000/01/rdf-schema#comment | "The effect of substitution of asparagine for arginine at position 276 (Ambler's numbering) on the properties of the extended-spectrum beta-lactamase CTX-M-4 was studied. Compared with CTX-M-4, the mutant beta-lactamase CTX-M-4(R276N) conferred lower levels of resistance to cefotaxime, ceftriaxone and aztreonam while the levels of resistance to penicillins and penicillin-inhibitor combinations were similar. Arg-276-->Asn substitution rendered CTX-M-4 slightly less susceptible to inhibition by clavulanate and tazobactam. It also caused a three-fold reduction in the relative rate of hydrolysis of cefotaxime. These results indicate that Arg-276 in CTX-M-type beta-lactamases may be implicated in hydrolysis of oxyimino-beta-lactams; they do not, however, support the hypothesis that Arg-276 is the functional equivalent of Arg-244 found in other class A beta-lactamases."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1574-6968.1998.tb13331.x"xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1574-6968.1998.tb13331.x"xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/author | "Gazouli M."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/author | "Gazouli M."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/author | "Legakis N.J."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/author | "Legakis N.J."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/author | "Tzouvelekis L.S."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/author | "Tzouvelekis L.S."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/name | "FEMS Microbiol. Lett."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/name | "FEMS Microbiol. Lett."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/pages | "289-293"xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/pages | "289-293"xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/title | "Effect of substitution of Asn for Arg-276 in the cefotaxime-hydrolyzing class A beta-lactamase CTX-M-4."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/title | "Effect of substitution of Asn for Arg-276 in the cefotaxime-hydrolyzing class A beta-lactamase CTX-M-4."xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/9868772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9868772 |
| http://purl.uniprot.org/citations/9868772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9868772 |
| http://purl.uniprot.org/citations/9868772 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9868772 |
| http://purl.uniprot.org/citations/9868772 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9868772 |