| http://purl.uniprot.org/citations/9878049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9878049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9878049 | http://www.w3.org/2000/01/rdf-schema#comment | "Amino acid transport across cellular membranes is mediated by multiple transporters with overlapping specificities. We recently have identified the vertebrate proteins which mediate Na+-independent exchange of large neutral amino acids corresponding to transport system L. This transporter consists of a novel amino acid permease-related protein (LAT1 or AmAT-L-lc) which for surface expression and function requires formation of disulfide-linked heterodimers with the glycosylated heavy chain of the h4F2/CD98 surface antigen. We show that h4F2hc also associates with other mammalian light chains, e.g. y+LAT1 from mouse and human which are approximately 48% identical with LAT1 and thus belong to the same family of glycoprotein-associated amino acid transporters. The novel heterodimers form exchangers which mediate the cellular efflux of cationic amino acids and the Na+-dependent uptake of large neutral amino acids. These transport characteristics and kinetic and pharmacological fingerprints identify them as y+L-type transport systems. The mRNA encoding my+LAT1 is detectable in most adult tissues and expressed at high levels in kidney cortex and intestine. This suggests that the y+LAT1-4F2hc heterodimer, besides participating in amino acid uptake/secretion in many cell types, is the basolateral amino acid exchanger involved in transepithelial reabsorption of cationic amino acids; hence, its defect might be the cause of the human genetic disease lysinuric protein intolerance."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.1.49"xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.1.49"xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Kuehn L.C."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Kuehn L.C."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Meier C."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Meier C."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Pfeiffer R."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Pfeiffer R."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Rossier G."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Rossier G."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Spindler B."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Spindler B."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Verrey F."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/author | "Verrey F."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/pages | "49-57"xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/pages | "49-57"xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/title | "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family."xsd:string |
| http://purl.uniprot.org/citations/9878049 | http://purl.uniprot.org/core/title | "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family."xsd:string |