| http://purl.uniprot.org/citations/9880530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9880530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9880530 | http://www.w3.org/2000/01/rdf-schema#comment | "ALG-2 is a 22-kDa calcium-binding protein necessary for cell death induced by different stimuli in 3DO T-cell hybridoma. 3DO cell clones depleted of ALG-2 protein exhibit normal caspases activation, suggesting that ALG-2 function is required downstream or is independent of caspase proteases activity for apoptosis to occur. Using the yeast two-hybrid screening system, we have isolated and characterized the mouse cDNA encoding for ALG-2 interacting protein 1 (AIP1), a novel protein that interacts with ALG-2. ALG-2 and AIP1 colocalize in the cytosol and the presence of calcium is an indispensable requisite for their association. Sequence alignment shows that AIP1 is highly similar to BRO1, a yeast protein related to components of the Pkc1p-MAP kinase cascade. Overexpression of a truncated form of AIP1 protects two different cell types from death induced by trophic factors withdrawal; thus, our data indicate that AIP1 cooperates with ALG-2 in executing the calcium-dependent requirements along the cell death pathway."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.3.1533"xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.3.1533"xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "Pellegrini L."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "Pellegrini L."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "D'Adamio L."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "D'Adamio L."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "Vito P."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "Vito P."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "Guiet C."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/author | "Guiet C."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/pages | "1533-1540"xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/pages | "1533-1540"xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/title | "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/title | "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction."xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/9880530 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9880530 |
| http://purl.uniprot.org/citations/9880530 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9880530 |