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| http://purl.uniprot.org/citations/9880789 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the TGF-beta superfamily regulate the growth and differentiation of various types of cells. Smads are recently identified proteins that mediate intracellular signaling of the TGF-beta superfamily. Smads are grouped into three classes depending on their structure and functions. R-Smads are phosphorylated by type I serine-threonine kinase receptors for TGF-beta superfamily members. R-Smads then associate with Co-Smads. Smad4 is the only vertebrate Co-Smad identified thus far, and is required for the signaling pathways of different ligands. The heteromeric Smad complex translocates into the nucleus, where it activates target genes. Anti-Smads inhibit signaling by R-Smads and Co-Smads. Smads bind to DNA directly or indirectly via other DNA binding proteins. R-Smads interact with transcriptional coactivators, and have intrinsic transactivation activity. Elucidation of the functions of Smads will provide the framework for research on TGF-beta superfamily signaling."xsd:string |
| http://purl.uniprot.org/citations/9880789 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.jbchem.a022273"xsd:string |
| http://purl.uniprot.org/citations/9880789 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/9880789 | http://purl.uniprot.org/core/author | "Kawabata M."xsd:string |
| http://purl.uniprot.org/citations/9880789 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9880789 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/9880789 | http://purl.uniprot.org/core/pages | "9-16"xsd:string |
| http://purl.uniprot.org/citations/9880789 | http://purl.uniprot.org/core/title | "Signal transduction of the TGF-beta superfamily by Smad proteins."xsd:string |
| http://purl.uniprot.org/citations/9880789 | http://purl.uniprot.org/core/volume | "125"xsd:string |
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