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http://purl.uniprot.org/citations/9883728http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9883728http://www.w3.org/2000/01/rdf-schema#comment"Hippocampal long-term potentiation (LTP) and long-term depression (LTD) are the most widely studied forms of synaptic plasticity thought to underlie spatial learning and memory. We report here that RARbeta deficiency in mice virtually eliminates hippocampal CA1 LTP and LTD. It also results in substantial performance deficits in spatial learning and memory tasks. Surprisingly, RXRgamma null mice exhibit a distinct phenotype in which LTD is lost whereas LTP is normal. Thus, while retinoid receptors contribute to both LTP and LTD, they do so in different ways. These findings not only genetically uncouple LTP and LTD but also reveal a novel and unexpected role for vitamin A in higher cognitive functions."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.org/dc/terms/identifier"doi:10.1016/s0896-6273(00)80654-6"xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Evans R.M."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Gage F.H."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Giguere V."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Chiang M.Y."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Stevens C.F."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Sucov H.M."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Kempermann G."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Misner D."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/author"Schikorski T."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/name"Neuron"xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/pages"1353-1361"xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/title"An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression."xsd:string
http://purl.uniprot.org/citations/9883728http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/9883728http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9883728
http://purl.uniprot.org/citations/9883728http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9883728
http://purl.uniprot.org/uniprot/#_A0A068BFV6-mappedCitation-9883728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9883728
http://purl.uniprot.org/uniprot/#_A0A068BD65-mappedCitation-9883728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9883728
http://purl.uniprot.org/uniprot/#_E9Q9V9-mappedCitation-9883728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9883728
http://purl.uniprot.org/uniprot/#_A0A286YCX1-mappedCitation-9883728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9883728
http://purl.uniprot.org/uniprot/#_A0A286YDP5-mappedCitation-9883728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9883728
http://purl.uniprot.org/uniprot/#_A0A068BES4-mappedCitation-9883728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9883728