| http://purl.uniprot.org/citations/9887098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9887098 | http://www.w3.org/2000/01/rdf-schema#comment | "The cell surface hyaluronan receptor CD44 promotes tumor growth and metastasis by mechanisms that remain poorly understood. We show here that CD44 associates with a proteolytic form of the matrix metalloproteinase-9 (MMP-9) on the surface of mouse mammary carcinoma and human melanoma cells. CD44-associated cell surface MMP-9 promotes cell-mediated collagen IV degradation in vitro and mediates tumor cell invasion of G8 myoblast monolayers. Several distinct CD44 isoforms coprecipitate with MMP-9 and CD44/MMP-9 coclustering is observed to be dependent on the ability of CD44 to form hyaluronan-induced aggregates. Disruption of CD44/MMP-9 cluster formation, by overexpression of soluble or truncated cell surface CD44, is shown to inhibit tumor invasiveness in vivo. Our observations indicate that CD44 serves to anchor MMP-9 on the cell surface and define a mechanism for CD44-mediated tumor invasion."xsd:string |
| http://purl.uniprot.org/citations/9887098 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.13.1.35"xsd:string |
| http://purl.uniprot.org/citations/9887098 | http://purl.uniprot.org/core/author | "Yu Q."xsd:string |
| http://purl.uniprot.org/citations/9887098 | http://purl.uniprot.org/core/author | "Stamenkovic I."xsd:string |
| http://purl.uniprot.org/citations/9887098 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9887098 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/9887098 | http://purl.uniprot.org/core/pages | "35-48"xsd:string |
| http://purl.uniprot.org/citations/9887098 | http://purl.uniprot.org/core/title | "Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion."xsd:string |
| http://purl.uniprot.org/citations/9887098 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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