| http://purl.uniprot.org/citations/9887331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9887331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9887331 | http://www.w3.org/2000/01/rdf-schema#comment | "Myotonic dystrophy (DM) is a neuromuscular disorder associated with CTG triplet repeat expansion in the myotonin protein kinase gene ( DMPK ). We previously proposed a hypothesis suggesting that the expanded CUG repeats sequester specific RNA-binding proteins and that such a sequestration results in abnormal RNA processing of several RNAs containing CUG repeats in multiple tissues affected in patients with DM. One of the members of the CUG-binding proteins, CUG-BP, has been identified previously. Here we describe the second member of this family, elav -type ribonucleoprotein (ETR-3), which is highly expressed in heart and is able to interact with CUG repeats. Screening of a mouse liver cDNA library with a CUG-BP probe identified two mETR-3 cDNAs. Two additional cDNAs from mouse heart were amplified by RT-PCR. These cDNAs differ by several insertions/deletions and might be generated via alternative splicing. Mouse ETR-3 has a mol. wt of 50 kDa and displays a high level of homology to CUG-BP protein. The organization of the RNA-binding domains (RBDs) within the ETR-3 molecule is similar to one within CUG-BP. A study of mETR-3 RNA-binding activity showed that the mETR-3 binds to (CUG)8repeats. Sequence analysis of mETR-3 indicates the presence of several CUG repeats within the mETR-3 mRNA. Both CUG-BP and mETR-3 bind to mETR-3 mRNA via CUG repeats, suggesting the possible involvement of CUG-BP-like proteins in the regulation of mETR-3 processing. Analysis of the tissue distribution of ETR-3 showed that in human cells, ETR-3 mRNA is highly expressed in heart, but is undetectable in other tissues examined. Our results suggest the existence of a family of proteins that bind to CUG repeats and might be affected in DM by expansion of CUG repeats."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/8.1.53"xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/8.1.53"xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/author | "Timchenko L.T."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/author | "Timchenko L.T."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/author | "Timchenko N.A."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/author | "Timchenko N.A."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/pages | "53-60"xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/pages | "53-60"xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/title | "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/title | "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy."xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/9887331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9887331 |
| http://purl.uniprot.org/citations/9887331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9887331 |
| http://purl.uniprot.org/citations/9887331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9887331 |
| http://purl.uniprot.org/citations/9887331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9887331 |