| http://purl.uniprot.org/citations/9888855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9888855 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphoinositide 3-kinase (PI3K) activation has been implicated in many cellular responses, including fibroblast growth, transformation, survival, and chemotaxis. Although PI3K is activated by several agents that stimulate T and B cells, the role of PI3K in lymphocyte function is not clear. The mouse gene encoding the PI3K adapter subunit p85alpha and its splice variants p55alpha and p50alpha was disrupted. Most p85alpha-p55alpha-p50alpha-/-mice die within days after birth. Lymphocyte development and function was studied with the use of the RAG2-deficient blastocyst complementation system. Chimeric mice had reduced numbers of peripheral mature B cells and decreased serum immunoglobulin. The B cells that developed had diminished proliferative responses to antibody to immunoglobulin M, antibody to CD40, and lipopolysaccharide stimulation and decreased survival after incubation with interleukin-4. In contrast, T cell development and proliferation was normal. This phenotype is similar to defects observed in mice lacking the tyrosine kinase Btk."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.283.5400.393"xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/author | "Cantley L.C."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/author | "Snapper S.B."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/author | "Davidson L."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/author | "Yu J.Y."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/author | "Fruman D.A."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/author | "Yballe C.M."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/pages | "393-397"xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/title | "Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha."xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/9888855 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9888855 |
| http://purl.uniprot.org/citations/9888855 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9888855 |
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