| http://purl.uniprot.org/citations/9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9889200 | http://www.w3.org/2000/01/rdf-schema#comment | "Both insulin-like growth factor-I (IGF-I) and brain-derived neurotrophic factor (BDNF) induce the differentiation of post-mitotic neuronal precursors, derived from embryonic day 14 (E14) mouse striatal multipotent stem cells. Here we ask whether this differentiation is mediated by a member of the POU-III class of neural transcription factors. Exposure of stem cell progeny to either IGF-I or BDNF resulted in a rapid upregulation of Brn-4 mRNA and protein. Indirect immunocytochemistry with Brn-4 antiserum showed that the protein was expressed in newly generated neurons. Other POU-III genes, such as Brn-1 and Brn-2, did not exhibit this upregulation. Basic FGF, a mitogen for these neuronal precursors, did not stimulate Brn-4 expression. In the E14 mouse striatum, Brn-4-immunoreactive cells formed a boundary between the nestin-immunoreactive cells of the ventricular zone and the beta-tubulin-immunoreactive neurons migrating into the mantle zone. Loss of Brn-4 function during the differentiation of stem cell-derived or primary E14 striatal neuron precursors, by inclusion of antisense oligonucleotides, caused a reduction in the number of beta-tubulin-immunoreactive neurons. These findings suggest that Brn-4 mediates, at least in part, the actions of epigenetic signals that induce striatal neuron-precursor differentiation."xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.2.444"xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/author | "Weiss S."xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/author | "Shimazaki T."xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/author | "Ryan A.K."xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/author | "Arsenijevic Y."xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/pages | "444-456"xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/title | "A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation."xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/9889200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9889200 |
| http://purl.uniprot.org/citations/9889200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9889200 |
| http://purl.uniprot.org/uniprot/P62515#attribution-A52A821FA2AC45D76AB6ED2EB4AC42F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9889200 |
| http://purl.uniprot.org/uniprot/#_D3Z7M4-mappedCitation-9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9889200 |
| http://purl.uniprot.org/uniprot/#_A0A2R8Y739-mappedCitation-9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9889200 |
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| http://purl.uniprot.org/uniprot/#_E9Q138-mappedCitation-9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9889200 |
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| http://purl.uniprot.org/uniprot/#_E9QNX9-mappedCitation-9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9889200 |
| http://purl.uniprot.org/uniprot/#_P62515-mappedCitation-9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9889200 |
| http://purl.uniprot.org/uniprot/#_Q3UVJ3-mappedCitation-9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9889200 |
| http://purl.uniprot.org/uniprot/#_P05017-mappedCitation-9889200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9889200 |