| http://purl.uniprot.org/citations/9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9890995 | http://www.w3.org/2000/01/rdf-schema#comment | "CD22 phosphorylation is an early event of B cell antigen receptor engagement and results in the recruitment of the negative regulatory tyrosine phosphatase, SHP-1. Peptides representing the potential phosphorylation sites within the cytoplasmic domain of CD22 have been used to stimulate SHP-1 catalytic activity and to inhibit the binding of SHP-1 to CD22 (Doody, G., Justement, L., Delibrias, C., Matthews, R., Lin, J., Thomas, M., and Fearon, D. (1995) Science 269, 242-244). However, the sites of phosphorylation within the cytoplasmic domain of CD22 and the importance of each for the recruitment and activation of SHP-1 remain unknown. Here we demonstrate that there are multiple sites within the cytoplasmic domain of CD22 that interact with the Src homology 2 domains of SHP-1. Nevertheless, a minimum of two tyrosines in CD22 is required for the association with SHP-1. Furthermore, both Src homology 2 domains of SHP-1 are necessary for efficient binding to CD22."xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.4.2303"xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/author | "Blasioli J."xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/author | "Thomas M.L."xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/author | "Paust S."xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/pages | "2303-2307"xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/title | "Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22."xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/9890995 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9890995 |
| http://purl.uniprot.org/citations/9890995 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH25-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH73-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ27-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SSS3-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A075B6P5-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A075B6S6-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A087WQV3-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A087WR31-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A087WR96-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_A0A087WST4-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_P0CF74-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |
| http://purl.uniprot.org/uniprot/#_P0CG04-mappedCitation-9890995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9890995 |