| http://purl.uniprot.org/citations/9891060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9891060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9891060 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor II (IGF-II) is a major fetal growth factor. The IGF-II gene generates multiple mRNAs with different 5' untranslated regions (5' UTRs) that are translated in a differential manner during development. We have identified a human family of three IGF-II mRNA-binding proteins (IMPs) that exhibit multiple attachments to the 5' UTR from the translationally regulated IGF-II leader 3 mRNA but are unable to bind to the 5' UTR from the constitutively translated IGF-II leader 4 mRNA. IMPs contain the unique combination of two RNA recognition motifs and four hnRNP K homology domains and are homologous to the Xenopus Vera and chicken zipcode-binding proteins. IMP localizes to subcytoplasmic domains in a growth-dependent and cell-specific manner and causes a dose-dependent translational repression of IGF-II leader 3 -luciferase mRNA. Mouse IMPs are produced in a burst at embryonic day 12.5 followed by a decline towards birth, and, similar to IGF-II, IMPs are especially expressed in developing epithelia, muscle, and placenta in both mouse and human embryos. The results imply that cytoplasmic 5' UTR-binding proteins control IGF-II biosynthesis during late mammalian development."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.19.2.1262"xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.19.2.1262"xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Lykke-Andersen J."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Lykke-Andersen J."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Johnsen A.H."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Johnsen A.H."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Nielsen J."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Nielsen J."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Christiansen J."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Christiansen J."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Nielsen F.C."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Nielsen F.C."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Wewer U.M."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/author | "Wewer U.M."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/pages | "1262-1270"xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/pages | "1262-1270"xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/title | "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development."xsd:string |
| http://purl.uniprot.org/citations/9891060 | http://purl.uniprot.org/core/title | "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development."xsd:string |