| http://purl.uniprot.org/citations/9895299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9895299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9895299 | http://www.w3.org/2000/01/rdf-schema#comment | "Dermatopontin, a recently found low-molecular-mass component of the extracellular matrix, was studied for its interaction with decorin and transforming growth factor beta (TGF-beta) and its influence on TGF-beta bioactivity. Dermatopontin reacted with decorin with an apparent Kd of 100 nM in a solid-phase assay. Dermatopontin inhibited the formation of the decorin-TGF-beta1 complex. Decorin also competed with dermatopontin for the binding of this cytokine. The dermatopontin-decorin complex bound 3-fold more TGF-beta1 than did each component individually, and binding was inhibited more strongly by decorin preincubated with dermatopontin than by dermatopontin or decorin alone. Dermatopontin augmented the biological activity of TGF-beta1, as analysed by the expression of luciferase in mink lung epithelial cells transfected with a plasminogen activator inhibitor-promoter-luciferase construct, although dermatopontin itself did not show apparent induction of luciferase. Dermatopontin showed weak inhibitory activity on the proliferation of mink lung epithelial cells, and it enhanced the growth-inhibitory activity of TGF-beta on these cells. Thus dermatopontin increases the cellular response to TGF-beta. These findings strongly suggest that dermatopontin modifies the behaviour of TGF-beta through interaction with decorin in the microenvironment of the extracellular matrix in vivo."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3370537"xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3370537"xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Fujiwara S."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Fujiwara S."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Okamoto O."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/author | "Okamoto O."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/pages | "537-541"xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/pages | "537-541"xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/title | "Dermatopontin interacts with transforming growth factor beta and enhances its biological activity."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/title | "Dermatopontin interacts with transforming growth factor beta and enhances its biological activity."xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/volume | "337"xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://purl.uniprot.org/core/volume | "337"xsd:string |
| http://purl.uniprot.org/citations/9895299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9895299 |
| http://purl.uniprot.org/citations/9895299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9895299 |