http://purl.uniprot.org/citations/9914332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9914332 | http://www.w3.org/2000/01/rdf-schema#comment | "A bacterial artificial chromosome (BAC) contig was constructed across the proximal part of the H2-M region from the major histocompatibility complex (Mhc) of mouse strain 129 (H2bc). The contig is composed of 28 clones that span approximately 1 megabasepair (Mb), from H2-T1 to Mog, and contains three H2-T genes and 18 H2-M genes. We report the fine mapping of the H2-M class I gene cluster, which includes the previously reported M4-M6, the M1 family, the M10 family, and four additional class I genes. All but two of the H2-M class I genes are conserved among haplotypes H2k, H2b, and H2bc, and only two genes are found in polymorphic HindIII fragments. Six evolutionarily conserved non-class I genes were mapped to a 180 kilobase interval in the distal part of the class I region in mouse, and their order Znf173-Rfb30-Tctex5-Tctex6-Tctex4-Mog was found conserved between human and mouse. In this Znf173-Mog interval, three mouse class I genes, M6, M4, and M5, which are conserved among haplotypes, occupy the same map position as the human HLA-A class I cluster, which varies among haplotypes and is diverged in sequence from the mouse genes. These results further support the view that class I gene diverge and evolve independently between species."xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.org/dc/terms/identifier | "doi:10.1007/s002510050479"xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/author | "Yoshino M."xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/author | "Kumanovics A."xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/author | "Fischer Lindahl K."xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/author | "Jones E.P."xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/pages | "183-195"xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/title | "Mhc class I and non-class I gene organization in the proximal H2-M region of the mouse."xsd:string |
http://purl.uniprot.org/citations/9914332 | http://purl.uniprot.org/core/volume | "49"xsd:string |
http://purl.uniprot.org/citations/9914332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9914332 |
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