| http://purl.uniprot.org/citations/9915833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9915833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9915833 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytoplasmic face of the Golgi contains a variety of proteins with coiled-coil domains. We identified one such protein in a yeast two-hybrid screen, using as bait the peripheral Golgi phosphatidylinositol(4,5)P2 5-phosphatase OCRL1 that is implicated in a human disease, the oculocerebrorenal syndrome. The approximately 2.8-kilobase mRNA is ubiquitously expressed and abundant in testis; it encodes a 731-amino acid protein with a predicted mass of 83 kDa. Antibodies against the sequence detect a novel approximately 84-kDa Golgi protein we termed golgin-84. Golgin-84 is an integral membrane protein with a single transmembrane domain close to its C terminus. In vitro, the protein inserts post-translationally into microsomal membranes with an N-cytoplasmic and C-lumen orientation. Cross-linking indicates that golgin-84 forms dimers, consistent with the prediction of an approximately 400-residue dimerizing coiled-coil domain in its N terminus. The dimerization potential is supported by a data base search that showed that the N-terminal 497 residues of golgin-84 contain a coiled-coil domain that when fused to the RET tyrosine kinase domain had the ability to activate it, forming the RET-II oncogene. Data base searching also indicates golgin-84 is similar in structure and sequence to giantin, a membrane protein that tethers coatamer complex I vesicles to the Golgi."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.5.2953"xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.5.2953"xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/author | "Nussbaum R.L."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/author | "Nussbaum R.L."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/author | "Srinivasan S."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/author | "Srinivasan S."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/author | "Bascom R.A."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/author | "Bascom R.A."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/pages | "2953-2962"xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/pages | "2953-2962"xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/title | "Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/title | "Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain."xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/9915833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9915833 |
| http://purl.uniprot.org/citations/9915833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9915833 |
| http://purl.uniprot.org/citations/9915833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9915833 |
| http://purl.uniprot.org/citations/9915833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9915833 |