| http://purl.uniprot.org/citations/9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9920658 | http://www.w3.org/2000/01/rdf-schema#comment | "The neuromedin B-preferring receptor (NMB-R) is one of the members of the bombesin (BN)-like peptide receptor subfamily in mammals. Previously, we have generated and characterized mice with targeted disruption of the two other BN-like peptide receptors, bombesin receptor subtype-3 (BRS-3) and gastrin-releasing peptide-preferring receptor (GRP-R). Here we describe the generation and analysis of NMB-R-deficient mice to investigate how NMB-R differs from BRS-3 and GRP-R. Compensation for NMB-R deficiency by overexpression of GRP-R and/or BRS-3 was not detected. Although the hypothermic effect of NMB was reduced by 50% in NMB-R-deficient mice, the effect of GRP infusion was comparable to the wild-type mice. In contrast, fundic smooth muscle contraction on stimulation with NMB or GRP was normal in NMB-R-deficient mice. Administration of GRP but not NMB suppressed glucose intake in both normal and NMB-R-deficient mice. These results suggest that the NMB-R has an essential role in thermoregulation, but not for smooth muscle contraction of the fundus or for the suppression of feeding behavior. In addition, the behavioral phenotypes of GRP-R-deficient mice were not observed in NMB-R-deficient mice. These data show that the functions of NMB-R and GRP-R are distinct, with only partial overlap."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-03-00948.1999"xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Okuyama S."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Wada K."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Sakai Y."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Ogura H."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Kamata K."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Ohki-Hamazaki H."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/author | "Watase K."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/pages | "948-954"xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/title | "Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor."xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/9920658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9920658 |
| http://purl.uniprot.org/citations/9920658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9920658 |
| http://purl.uniprot.org/uniprot/#_A0A087WQJ7-mappedCitation-9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9920658 |
| http://purl.uniprot.org/uniprot/#_A0A087WP36-mappedCitation-9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9920658 |
| http://purl.uniprot.org/uniprot/#_A0A087WPA3-mappedCitation-9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9920658 |
| http://purl.uniprot.org/uniprot/#_A0A087WRS7-mappedCitation-9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9920658 |
| http://purl.uniprot.org/uniprot/#_P21729-mappedCitation-9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9920658 |
| http://purl.uniprot.org/uniprot/#_O54798-mappedCitation-9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9920658 |
| http://purl.uniprot.org/uniprot/#_O54799-mappedCitation-9920658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9920658 |