| http://purl.uniprot.org/citations/9922094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9922094 | http://www.w3.org/2000/01/rdf-schema#comment | "The orphan nuclear receptor steroidogenic factor 1 (SF-1) was initially isolated as a key regulator of the cytochrome P450 steroid hydroxylases in adrenocortical and gonadal cells. Subsequent analyses of SF-1 knockout mice have expanded considerably our understanding of the roles that SF-1 plays in endocrine development. These SF-1 knockout mice lacked adrenal glands and gonads, with consequent male-to-female sex reversal of their internal and external genitalia. Thus, SF-1 is essential for the embryonic survival of the primary steroidogenic organs. They further exhibited impaired gonadotrope function and agenesis of the ventromedial hypothalamic nucleus, establishing that SF-1 contributes to reproductive function at all three levels of the hypothalamic-pituitary-gonadal axis. This report reviews experiments that have defined these critical roles of SF-1 in endocrine development, and highlights areas of ongoing investigation."xsd:string |
| http://purl.uniprot.org/citations/9922094 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0303-7207(98)00164-6"xsd:string |
| http://purl.uniprot.org/citations/9922094 | http://purl.uniprot.org/core/author | "Parker K.L."xsd:string |
| http://purl.uniprot.org/citations/9922094 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9922094 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/9922094 | http://purl.uniprot.org/core/pages | "15-20"xsd:string |
| http://purl.uniprot.org/citations/9922094 | http://purl.uniprot.org/core/title | "The roles of steroidogenic factor 1 in endocrine development and function."xsd:string |
| http://purl.uniprot.org/citations/9922094 | http://purl.uniprot.org/core/volume | "145"xsd:string |
| http://purl.uniprot.org/citations/9922094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9922094 |
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