| http://purl.uniprot.org/citations/9927321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9927321 | http://www.w3.org/2000/01/rdf-schema#comment | "The heart has been recognized as a major target of thyroid hormone action. Our study investigates both the regulation of cardiac-specific genes and contractile behavior of the heart in the presence of a mutant thyroid hormone receptor beta1 (T3Rbeta1-delta337T) derived from the S kindred. The mutant receptor was originally identified in a patient with generalized resistance to thyroid hormone. Cardiac expression of the mutant receptor was achieved by a transgenic approach in mice. As the genes for myosin heavy chains (MHC alpha and MHC beta) and the cardiac sarcoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA2) are known to be regulated by T3, their cardiac expression was analyzed. The messenger RNA levels for MHC alpha and SERCA2 were markedly down-regulated, MHC beta messenger RNA was up-regulated. Although T3 levels were normal in these animals, this pattern of cardiac gene expression mimics a hypothyroid phenotype. Cardiac muscle contraction was significantly prolonged in papillary muscles from transgenic mice. The electrocardiogram of transgenic mice showed a substantial prolongation of the QRS interval. Changes in cardiac gene expression, cardiac muscle contractility, and electrocardiogram are compatible with a hypothyroid cardiac phenotype despite normal T3 levels, indicating a dominant negative effect of the T3Rbeta mutant."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.140.2.6527"xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Meyer M."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Gloss B."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Dillmann W.H."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Sayen M.R."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Usala S.J."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Trost S.U."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Bluhm W.F."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/author | "Swanson E.A."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/pages | "897-902"xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/title | "Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family."xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://purl.uniprot.org/core/volume | "140"xsd:string |
| http://purl.uniprot.org/citations/9927321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9927321 |
| http://purl.uniprot.org/citations/9927321 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9927321 |
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| http://purl.uniprot.org/uniprot/#_A0A286YDB1-mappedCitation-9927321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9927321 |
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| http://purl.uniprot.org/uniprot/#_B2RXX9-mappedCitation-9927321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9927321 |
| http://purl.uniprot.org/uniprot/#_B2RY26-mappedCitation-9927321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9927321 |
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| http://purl.uniprot.org/uniprot/#_A0A2I3BQV3-mappedCitation-9927321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9927321 |