| http://purl.uniprot.org/citations/9927446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9927446 | http://www.w3.org/2000/01/rdf-schema#comment | "The RFC1 gene encodes the large subunit of the yeast clamp loader (RFC) that is a component of eukaryotic DNA polymerase holoenzymes. We identified a mutant allele of RFC1 (rfc1::Tn3) from a large collection of Saccharomyces cerevisiae mutants that were inviable when present in a rad52 null mutation background. Analysis of rfc1::Tn3 strains indicated that they displayed both a mutator and repeat-tract instability phenotype. Strains bearing this allele were characterized in combination with mismatch repair (msh2Delta, pms1Delta), double-strand break repair (rad52), and DNA replication (pol3-01, pol30-52, rth1Delta/rad27Delta) mutations in both forward mutation and repeat-tract instability assays. This analysis indicated that the rfc1::Tn3 allele displays synthetic lethality with pol30, pol3, and rad27 mutations. Measurement of forward mutation frequencies in msh2Delta rfc1:Tn3 and pms1Delta rfc1:Tn3 strains indicated that the rfc1::Tn3 mutant displayed a mutation frequency that appeared nearly multiplicative with the mutation frequency exhibited by mismatch-repair mutants. In repeat-tract instability assays, however, the rfc1::Tn3 mutant displayed a tract instability phenotype that appeared epistatic to the phenotype displayed by mismatch-repair mutants. From these data we propose that defects in clamp loader function result in DNA replication errors, a subset of which are acted upon by the mismatch-repair system."xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/151.2.499"xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/author | "Xie Y."xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/author | "Alani E."xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/author | "Counter C."xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/pages | "499-509"xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/title | "Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader."xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/9927446 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9927446 |
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| http://purl.uniprot.org/uniprot/#_P15873-mappedCitation-9927446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9927446 |
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| http://purl.uniprot.org/uniprot/#_P14242-mappedCitation-9927446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9927446 |
| http://purl.uniprot.org/uniprot/P06778 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9927446 |
| http://purl.uniprot.org/uniprot/P15436 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9927446 |
| http://purl.uniprot.org/uniprot/P15873 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9927446 |
| http://purl.uniprot.org/uniprot/P14242 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9927446 |
| http://purl.uniprot.org/uniprot/P25847 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9927446 |
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