| http://purl.uniprot.org/citations/9931293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9931293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9931293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/9931293 | http://www.w3.org/2000/01/rdf-schema#comment | "This report describes the activity of recombinant human Rdh5 (11-cis-retinol dehydrogenase) with steroids and retinoids and expression of the Rdh5 mRNA in extra-ocular human tissue. The data show that Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism and recognizes 5alpha-androstan-3alpha,17beta-diol and androsterone as substrates (3alpha-hydroxysteroid dehydrogenase activity), but not testosterone, dihydrotestosterone, oestradiol and corticosterone (lack of 17beta-hydroxysteroid and 11beta-hydroxysteroid dehydrogenase activities). Rdh5 mRNA expression was widespread in extra-ocular tissues with human liver (100% relative expression in extra-ocular tissues only) and mammary gland (97% relative to liver) showing the most intense signals. Other noteworthy relatively intense expression sites included colon (45%), thymus (43%), small intestine (39%), kidney (37%), bladder (29%), pancreas and spleen (28% each), heart (26%), uterus and ovary (25% each), testis (22%) and spinal cord (24%). Human fetal tissues also expressed Rdh5 with fetal liver showing the most intense expression among the fetal tissues (20%). Considered along with the identical nucleotide sequences in the untranslated regions of human Rdh5 and human 9-cis-retinol dehydrogenase cDNAs and the nearly identical nucleotide sequences overall (99% identity), the current results suggest that the two cDNAs represent a single gene product."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3380023"xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3380023"xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Chai X."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Chai X."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Eriksson U."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Eriksson U."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Napoli J.L."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/author | "Napoli J.L."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/pages | "23-27"xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/pages | "23-27"xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/title | "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/title | "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue."xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/volume | "338"xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://purl.uniprot.org/core/volume | "338"xsd:string |
| http://purl.uniprot.org/citations/9931293 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9931293 |