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| http://purl.uniprot.org/citations/9950951 | http://www.w3.org/2000/01/rdf-schema#comment | "Tight regulation of the rates of cell proliferation and apoptosis is critical for normal nephrogenesis. Nephrogenesis is profoundly affected by the loss of bcl-2 expression. Bcl-2-deficient (bcl-2 -/-) mice are born with renal hypoplasia and succumb to renal failure secondary to renal multicystic disease. Cell-cell and cell-matrix interactions impact tissue architecture by modulating cell proliferation, migration, differentiation, and apoptosis. E-cadherin mediates calcium-dependent homotypic cell-cell interactions that are stabilized by its association with catenins and the actin cytoskeleton. The contribution of altered cell-cell interactions to renal cystic disease has not been delineated. Cystic kidneys from bcl-2 -/-mice displayed nuclear localization of beta-catenin and loss of apical brush border actin staining. The protein levels of alpha-catenin, beta-catenin, actin, and E-cadherin were not altered in cystic kidneys compared with normal kidneys. Therefore, an altered distribution of beta-catenin and actin, in kidneys from bcl-2 -/-mice, may indicate improper cell-cell interactions interfering with renal maturation and contributing to renal cyst formation."xsd:string |
| http://purl.uniprot.org/citations/9950951 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.1999.276.2.f210"xsd:string |
| http://purl.uniprot.org/citations/9950951 | http://purl.uniprot.org/core/author | "Sorenson C.M."xsd:string |
| http://purl.uniprot.org/citations/9950951 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9950951 | http://purl.uniprot.org/core/name | "Am J Physiol"xsd:string |
| http://purl.uniprot.org/citations/9950951 | http://purl.uniprot.org/core/pages | "F210-7"xsd:string |
| http://purl.uniprot.org/citations/9950951 | http://purl.uniprot.org/core/title | "Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice."xsd:string |
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