| http://purl.uniprot.org/citations/9971821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9971821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9971821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9971821 | http://www.w3.org/2000/01/rdf-schema#comment | "A 4.7-kb region of DNA sequence contained at the right end of the myxoma virus EcoRI-G2 fragment located 24 kb from the right end of the 163-kb genome has been determined. This region of the myxoma virus genome encodes homologs of the vaccinia virus genes A51R, A52R, A55R, A56R, and B1R; the myxoma virus gene equivalents have been given the prefix M. The MA55 gene encodes a protein belonging to the kelch family of actin-binding proteins, while the MA56 gene encodes a member of the immunoglobulin superfamily related to a variety of cellular receptors and adhesion molecules. A novel myxoma virus early gene, MST3N, is a member of the eukaryotic sialyltransferase gene family located between genes MA51 and MA52. Detergent lysates prepared from myxoma virus-infected cell cultures contained a virally encoded sialyltransferase activity that catalyzed the transfer of sialic acid (Sia) from CMP-Sia to an asialofetuin glycoprotein acceptor. Analysis of the in vitro-sialylated glycoprotein acceptor by digestion with N-glycosidase F and by lectin binding suggested that the MST3N gene encodes an enzyme with Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase specificity for the N-linked oligosaccharide of glycoprotein. Lectin binding assays demonstrated that alpha2,3-sialyltransferase activity is expressed by several known leporipoxviruses that naturally infect Sylvilagus rabbits. The sialyltransferase is nonessential for myxoma virus replication in cell culture; however, disruption of the MST3N gene caused attenuation in vivo. The possible implications of the myxoma virus-expressed sialyltransferase in terms of the host's defenses against infection are discussed."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.73.3.2376-2384.1999"xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9971821 |
| http://purl.uniprot.org/citations/9971821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9971821 |
| http://purl.uniprot.org/citations/9971821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9971821 |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Jackson R.J."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Jackson R.J."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Jackson R.J."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Kerr P.J."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Kerr P.J."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Kerr P.J."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Hall D.F."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Hall D.F."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/author | "Hall D.F."xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/pages | "2376-2384"xsd:string |
| http://purl.uniprot.org/citations/9971821 | http://purl.uniprot.org/core/pages | "2376-2384"xsd:string |