| http://purl.uniprot.org/citations/9973372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9973372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9973372 | http://www.w3.org/2000/01/rdf-schema#comment | "BY55 is a human cell surface molecule whose expression is restricted to NK cells, a subset of circulating CD8+ T lymphocytes, and all intestinal intraepithelial T lymphocytes. Here, we report that BY55 is a novel NK receptor showing broad specificity for both classical and nonclassical MHC class I molecules, and that optimal binding requires a prior aggregation of MHC class I complexes. Using BY55 transfectants, we have identified functional consequences of MHC class I/ligand interactions for the class I-bearing cell. The triggering of MHC class I molecules on human T cell clones by BY55 delivered a potent proliferative signal in the presence of soluble CD3 mAb. The costimulatory signal provided by MHC class I ligation was only seen in activated, and not resting, peripheral blood T cells. This observation represents an additional and/or alternative pathway to CD28 costimulation and may be of particular relevance in memory T cells lacking CD28, such as intestinal intraepithelial T lymphocytes, which are CD28- but BY55+."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Agrawal S."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Agrawal S."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Freeman G.J."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Freeman G.J."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Roth P."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Roth P."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Bensussan A."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Bensussan A."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Bolton W."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Bolton W."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Boumsell L."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Boumsell L."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Bouteiller P.L."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Bouteiller P.L."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Marquet J."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Marquet J."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Ogg G."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Ogg G."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Tawab A."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/author | "Tawab A."xsd:string |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9973372 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |