| http://purl.uniprot.org/citations/9973601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9973601 | http://www.w3.org/2000/01/rdf-schema#comment | "We have studied the mutant phenotypes brought about during early embryogenesis by mutation in the gammaTub37C gene, one of the two isoforms of gamma-tubulin that have been identified in Drosophila. We have focused our attention on fs(2)TW1(1) and fs(2)TW1(RU34), a null and a hypomorph allele of this gene, whose sequences we report in this work. We have found that the abnormal meiotic figures observed in mutant stage 14 oocytes are not observed in laid oocytes or fertilised embryos, suggesting that these abnormal meiotic figures are not terminally arrested. We have also concluded that both null and hypomorph alleles lead to a total arrest of nuclear proliferation during early embryogenesis. This is in contrast to their effect on female meiosis-I where hypomorph alleles display a much weaker phenotype. Finally, we have observed that null and hypomorph alleles lead to some distinct phenotypes. Unfertilised laid oocytes and fertilised embryos deficient for gammaTub37C do not contain polar bodies and have a few bipolar microtubule arrays. In contrast, oocytes and embryos from weaker alleles do not have these microtubule arrays, but do contain polar bodies, or polar-body-like structures. These results indicate that gammaTub37C is essential for nuclear proliferation in the early Drosophila embryo."xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.112.5.659"xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/author | "Gonzalez C."xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/author | "Llamazares S."xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/author | "Tavosanis G."xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/pages | "659-667"xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/title | "Cytological characterisation of the mutant phenotypes produced during early embryogenesis by null and loss-of-function alleles of the gammaTub37C gene in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/9973601 | http://purl.uniprot.org/core/volume | "112"xsd:string |
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