RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/9990008http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9990008http://www.w3.org/2000/01/rdf-schema#comment"The pyruvate dehydrogenase multienzyme complex (Mr of 5-10 million) is assembled around a structural core formed of multiple copies of dihydrolipoyl acetyltransferase (E2p), which exhibits the shape of either a cube or a dodecahedron, depending on the source. The crystal structures of the 60-meric dihydrolipoyl acyltransferase cores of Bacillus stearothermophilus and Enterococcus faecalis pyruvate dehydrogenase complexes were determined and revealed a remarkably hollow dodecahedron with an outer diameter of approximately 237 A, 12 large openings of approximately 52 A diameter across the fivefold axes, and an inner cavity with a diameter of approximately 118 A. Comparison of cubic and dodecahedral E2p assemblies shows that combining the principles of quasi-equivalence formulated by Caspar and Klug [Caspar, D. L. & Klug, A. (1962) Cold Spring Harbor Symp. Quant. Biol. 27, 1-4] with strict Euclidean geometric considerations results in predictions of the major features of the E2p dodecahedron matching the observed features almost exactly."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.org/dc/terms/identifier"doi:10.1073/pnas.96.4.1240"xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/author"Perham R.N."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/author"Hol W.G."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/author"Allen M.D."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/author"Izard T."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/author"Aevarsson A."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/author"Westphal A.H."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/author"de Kok A."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/pages"1240-1245"xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/title"Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes."xsd:string
http://purl.uniprot.org/citations/9990008http://purl.uniprot.org/core/volume"96"xsd:string
http://purl.uniprot.org/citations/9990008http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9990008
http://purl.uniprot.org/citations/9990008http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9990008
http://purl.uniprot.org/uniprot/#_P11961-mappedCitation-9990008http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9990008
http://purl.uniprot.org/uniprot/P11961http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/9990008