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http://purl.uniprot.org/citations/9990011http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9990011http://www.w3.org/2000/01/rdf-schema#comment"We have constructed mutants of chymotrypsin inhibitor 2 with short glutamine repeats inserted into its inhibitory loop. These mutants oligomerize when expressed in Escherichia coli. The dimer of a mutant with four glutamines now has been crystallized, and its structure has been solved by molecular replacement by using the wild-type monomer as a search model. The structure of each half of the dimer is found to be the same as that of the wild-type monomer, except around the glutamine insertion. It was proposed that the components of the oligomers are held together by hydrogen bonds between the main-chain and side-chain amides of the glutamine repeats. Instead, they appear to form by swapping domains on folding in E. coli, and the glutamine repeats connecting the components of the dimers are disordered."xsd:string
http://purl.uniprot.org/citations/9990011http://purl.org/dc/terms/identifier"doi:10.1073/pnas.96.4.1257"xsd:string
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/author"Chen Y.W."xsd:string
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/author"Stott K."xsd:string
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/author"Perutz M.F."xsd:string
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/pages"1257-1261"xsd:string
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/title"Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat."xsd:string
http://purl.uniprot.org/citations/9990011http://purl.uniprot.org/core/volume"96"xsd:string
http://purl.uniprot.org/citations/9990011http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9990011
http://purl.uniprot.org/citations/9990011http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9990011
http://purl.uniprot.org/uniprot/#_P01053-mappedCitation-9990011http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9990011
http://purl.uniprot.org/uniprot/P01053http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/9990011