| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Enzyme |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.7.11.- |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.7.-.- |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.-.-.- |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/core/Enzyme |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#comment | "While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#comment | "This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2000/01/rdf-schema#comment | "Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#prefLabel | "mitogen-activated protein kinase kinase kinase"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11042189 |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8940179 |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8334704 |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#altLabel | "MAP kinase kinase kinase"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#altLabel | "MEK kinase"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#altLabel | "MEKK"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#altLabel | "MAP3K"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#altLabel | "MLTK"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#altLabel | "MAPKKK"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#altLabel | "MLK-like mitogen-activated protein triple kinase"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://purl.uniprot.org/core/replaces | http://purl.uniprot.org/enzyme/2.7.1.37 |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://purl.uniprot.org/core/activity | http://purl.uniprot.org/enzyme/2.7.11.25#SIPABF32A1AD40E58B2 |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://purl.uniprot.org/core/activity | http://purl.uniprot.org/enzyme/2.7.11.25#SIP81BD4F43BC20BF5F |
| http://purl.uniprot.org/enzyme/2.7.11.25 | http://www.w3.org/2004/02/skos/core#broaderTransitive | http://purl.uniprot.org/enzyme/2.7.11.- |