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| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.7.-.- |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.-.-.- |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/core/Enzyme |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.7.12.- |
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| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#comment | "It is required for activation of EC 2.7.11.24."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2000/01/rdf-schema#comment | "A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation."xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2004/02/skos/core#prefLabel | "mitogen-activated protein kinase kinase"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8388392 |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8157000 |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8393135 |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8621675 |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7731726 |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8004006 |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2004/02/skos/core#altLabel | "MAPKK"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2004/02/skos/core#altLabel | "MAP kinase kinase"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2004/02/skos/core#altLabel | "MKK"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2004/02/skos/core#altLabel | "MEK"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://www.w3.org/2004/02/skos/core#altLabel | "MAP2K"xsd:string |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/activity | http://purl.uniprot.org/enzyme/2.7.12.2#SIP4EDF633C735C93B2 |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/activity | http://purl.uniprot.org/enzyme/2.7.12.2#SIP81BD4F43BC20BF5F |
| http://purl.uniprot.org/enzyme/2.7.12.2 | http://purl.uniprot.org/core/activity | http://purl.uniprot.org/enzyme/2.7.12.2#SIPABF32A1AD40E58B2 |