| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Enzyme |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/3.4.-.- |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/3.4.22.- |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/3.-.-.- |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/core/Enzyme |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63)."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Endogenous substrates for caspase-8 include procaspase-3, the pro-apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8 activity modulator FLIPL."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Linked to cell surface death receptors such as Fas."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Belongs to peptidase family C14."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Has a preference for Glu at P3 and prefers small residues, such as Gly, Ser and Ala at the P1' position."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Contains two tandem death effector domains (DEDs) in its N-terminal prodomain, which play a role in procaspase activation."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Has very broad P4 specificity, tolerating substrates with Asp, Val or Leu in this position."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "When Fas is aggregated by the Fas ligand, procaspase-8 is recruited to the death receptor where it is activated."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2000/01/rdf-schema#comment | "Apical activator of the extrinsic (death receptor) apoptosis pathway, triggered by death receptor ligation."xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2004/02/skos/core#prefLabel | "caspase-8"xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8681376 |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8681377 |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10964557 |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11104820 |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15209560 |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16186808 |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2004/02/skos/core#altLabel | "FADD-homologous ICE/CED-3-like protease"xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2004/02/skos/core#altLabel | "MACH"xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2004/02/skos/core#altLabel | "CAP4"xsd:string |
| http://purl.uniprot.org/enzyme/3.4.22.61 | http://www.w3.org/2004/02/skos/core#altLabel | "Mch5"xsd:string |