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http://purl.uniprot.org/citations/10981963http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10981963http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10981963http://www.w3.org/2000/01/rdf-schema#comment"BCL-6, a transcriptional repressor frequently translocated in lymphomas, regulates germinal center B cell differentiation and inflammation. DNA microarray screening identified genes repressed by BCL-6, including many lymphocyte activation genes, suggesting that BCL-6 modulates B cell receptor signals. BCL-6 repression of two chemokine genes, MIP-1alpha and IP-10, may also attenuate inflammatory responses. Blimp-1, another BCL-6 target, is important for plasmacytic differentiation. Since BCL-6 expression is silenced in plasma cells, repression of blimp-1 by BCL-6 may control plasmacytic differentiation. Indeed, inhibition of BCL-6 function initiated changes indicative of plasmacytic differentiation, including decreased expression of c-Myc and increased expression of the cell cycle inhibitor p27kip1. These data suggest that malignant transformation by BCL-6 involves inhibition of differentiation and enhanced proliferation."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)00020-0"xsd:string
http://purl.uniprot.org/citations/10981963http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)00020-0"xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"He Y."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"He Y."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Yu X."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Yu X."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Staudt L.M."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Staudt L.M."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Shaffer A.L."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Shaffer A.L."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Boldrick J."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Boldrick J."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Chan E.P."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/author"Chan E.P."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/pages"199-212"xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/pages"199-212"xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/title"BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control."xsd:string
http://purl.uniprot.org/citations/10981963http://purl.uniprot.org/core/title"BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control."xsd:string