| http://purl.uniprot.org/citations/23353684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23353684 | http://www.w3.org/2000/01/rdf-schema#comment | "α(2)-Macroglobulin (α(2)M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of α(2)M with proteases results in an 'activated' conformation, where the proteases become covalently-linked within the interior of a cage-like structure formed by α(2)M. This study investigates, the effect of activation on the ability of α(2)M to inhibit amyloid formation by Aβ(1-42) and I59T human lysozyme and shows that protease-activated α(2)M can act via two distinct mechanisms: (i) by trapping proteases that remain able to degrade polypeptide chains and (ii) by a chaperone action that prevents misfolded clients from continuing along the amyloid forming pathway."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2013.01.020"xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Dobson C.M."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Wilson M.R."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Yerbury J.J."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Ecroyd H."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Kumita J.R."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Wyatt A.R."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Constantinescu P."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/pages | "398-403"xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/title | "Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms."xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/volume | "587"xsd:string |
| http://purl.uniprot.org/citations/23353684 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23353684 |
| http://purl.uniprot.org/citations/23353684 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23353684 |
| http://purl.uniprot.org/uniprot/P05067#attribution-250FE697C6563A558918CB62DF961AAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23353684 |
| http://purl.uniprot.org/uniprot/P61626#attribution-250FE697C6563A558918CB62DF961AAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23353684 |
| http://purl.uniprot.org/uniprot/P00711#attribution-250FE697C6563A558918CB62DF961AAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23353684 |
| http://purl.uniprot.org/uniprot/#_P61626-mappedCitation-23353684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23353684 |
| http://purl.uniprot.org/uniprot/#_P00711-mappedCitation-23353684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23353684 |
| http://purl.uniprot.org/uniprot/#_P01023-mappedCitation-23353684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23353684 |
| http://purl.uniprot.org/uniprot/#_L0R6B6-mappedCitation-23353684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23353684 |
| http://purl.uniprot.org/uniprot/#_P05067-mappedCitation-23353684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23353684 |