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Entry version 190 (18 Sep 2019)
Sequence version 2 (01 Oct 1996)
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Protein

Hemopexin

Gene

HPX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Miscellaneous

The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi79Iron (heme 1 axial ligand)By similarity1
Metal bindingi150Iron (heme 1 axial ligand)By similarity1
Metal bindingi236Iron (heme 2 axial ligand)By similarity1
Metal bindingi293Iron (heme 2 axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2168880 Scavenging of heme from plasma

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P02790

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemopexin
Alternative name(s):
Beta-1B-glycoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HPX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5171 HPX

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142290 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02790

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3263

Open Targets

More...
OpenTargetsi
ENSG00000110169

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29441

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HPX

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1708182

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 232 PublicationsAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002140624 – 462Hemopexin1 PublicationAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24O-linked (GalNAc...) threonine3 Publications1
Glycosylationi29O-linked (GalNAc...) threonine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 2311 Publication
Glycosylationi64N-linked (GlcNAc...) (complex) asparagine3 Publications1
Disulfide bondi149 ↔ 1541 Publication
Glycosylationi187N-linked (GlcNAc...) (complex) asparagine8 Publications1
Disulfide bondi188 ↔ 2001 Publication
Glycosylationi240N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi246N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi257 ↔ 4601 Publication
Disulfide bondi366 ↔ 4081 Publication
Disulfide bondi418 ↔ 4351 Publication
Glycosylationi453N-linked (GlcNAc...) (complex) asparagine6 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is minor compared to glycosylation at Thr-24 and Thr-29.9 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-1131

Encyclopedia of Proteome Dynamics

More...
EPDi
P02790

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P02790

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P02790

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02790

PeptideAtlas

More...
PeptideAtlasi
P02790

PRoteomics IDEntifications database

More...
PRIDEi
P02790

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51598

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P02790

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00022488

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P02790

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P02790

GlyConnect protein glycosylation platform

More...
GlyConnecti
757

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02790

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02790

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P02790

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110169 Expressed in 100 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02790 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02790 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016725

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FLVCR1.

1 Publication

(Microbial infection)

Interacts with hepatitis E virus/HEV protein ORF3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109500, 12 interactors

Database of interacting proteins

More...
DIPi
DIP-38339N

Protein interaction database and analysis system

More...
IntActi
P02790, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265983

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02790

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 93Hemopexin 1Add BLAST41
Repeati94 – 139Hemopexin 2Add BLAST46
Repeati140 – 184Hemopexin 3Add BLAST45
Repeati185 – 231Hemopexin 4Add BLAST47
Repeati259 – 304Hemopexin 5Add BLAST46
Repeati305 – 352Hemopexin 6Add BLAST48
Repeati357 – 396Hemopexin 7Add BLAST40
Repeati400 – 450Hemopexin 8Add BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 40O-glycosylated at one siteAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hemopexin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1565 Eukaryota
ENOG410XQ5D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009178

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112887

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02790

KEGG Orthology (KO)

More...
KOi
K18977

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSHYWRL

Database of Orthologous Groups

More...
OrthoDBi
1422977at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02790

TreeFam database of animal gene trees

More...
TreeFami
TF331201

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00094 HX, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.110.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016358 Hemopexin
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00045 Hemopexin, 5 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002551 Hemopexin_chordata, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00120 HX, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50923 SSF50923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00024 HEMOPEXIN, 2 hits
PS51642 HEMOPEXIN_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC
60 70 80 90 100
SDGWSFDATT LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA
110 120 130 140 150
FRQGHNSVFL IKGDKVWVYP PEKKEKGYPK LLQDEFPGIP SPLDAAVECH
160 170 180 190 200
RGECQAEGVL FFQGDREWFW DLATGTMKER SWPAVGNCSS ALRWLGRYYC
210 220 230 240 250
FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN GTGHGNSTHH
260 270 280 290 300
GPEYMRCSPH LVLSALTSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ
310 320 330 340 350
WPQGPSAVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG
360 370 380 390 400
TPHGIILDSV DAAFICPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH
410 420 430 440 450
EKVDGALCME KSLGPNSCSA NGPGLYLIHG PNLYCYSDVE KLNAAKALPQ
460
PQNVTSLLGC TH
Length:462
Mass (Da):51,676
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i054B44D0603763B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BS19Q9BS19_HUMAN
Epididymis secretory sperm binding ...
HPX
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA26382 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti411K → R in BAG36404 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04713752D → N. Corresponds to variant dbSNP:rs10839564Ensembl.1
Natural variantiVAR_03399083R → W. Corresponds to variant dbSNP:rs12117Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M36803
, M36796, M36799, M36800, M36801, M36802 Genomic DNA Translation: AAA58678.1
AK313648 mRNA Translation: BAG36404.1
J03048 mRNA Translation: AAA52704.1
X02537 mRNA Translation: CAA26382.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7763.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I56456 OQHU

NCBI Reference Sequences

More...
RefSeqi
NP_000604.1, NM_000613.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265983; ENSP00000265983; ENSG00000110169

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3263

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3263

UCSC genome browser

More...
UCSCi
uc001mdg.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36803
, M36796, M36799, M36800, M36801, M36802 Genomic DNA Translation: AAA58678.1
AK313648 mRNA Translation: BAG36404.1
J03048 mRNA Translation: AAA52704.1
X02537 mRNA Translation: CAA26382.1 Different initiation.
CCDSiCCDS7763.1
PIRiI56456 OQHU
RefSeqiNP_000604.1, NM_000613.2

3D structure databases

SMRiP02790
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109500, 12 interactors
DIPiDIP-38339N
IntActiP02790, 10 interactors
STRINGi9606.ENSP00000265983

PTM databases

CarbonylDBiP02790
GlyConnecti757
iPTMnetiP02790
PhosphoSitePlusiP02790
UniCarbKBiP02790

Polymorphism and mutation databases

BioMutaiHPX
DMDMi1708182

2D gel databases

DOSAC-COBS-2DPAGEiP02790
REPRODUCTION-2DPAGEiIPI00022488
SWISS-2DPAGEiP02790

Proteomic databases

CPTACinon-CPTAC-1131
EPDiP02790
jPOSTiP02790
MassIVEiP02790
PaxDbiP02790
PeptideAtlasiP02790
PRIDEiP02790
ProteomicsDBi51598

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3263
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265983; ENSP00000265983; ENSG00000110169
GeneIDi3263
KEGGihsa:3263
UCSCiuc001mdg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3263
DisGeNETi3263

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HPX
HGNCiHGNC:5171 HPX
HPAiCAB016725
MIMi142290 gene
neXtProtiNX_P02790
OpenTargetsiENSG00000110169
PharmGKBiPA29441

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00390000009178
HOGENOMiHOG000112887
InParanoidiP02790
KOiK18977
OMAiGSHYWRL
OrthoDBi1422977at2759
PhylomeDBiP02790
TreeFamiTF331201

Enzyme and pathway databases

ReactomeiR-HSA-2168880 Scavenging of heme from plasma
SIGNORiP02790

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HPX human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Hemopexin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3263

Pharos

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Pharosi
P02790

Protein Ontology

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PROi
PR:P02790

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110169 Expressed in 100 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP02790 baseline and differential
GenevisibleiP02790 HS

Family and domain databases

CDDicd00094 HX, 2 hits
Gene3Di2.110.10.10, 2 hits
InterProiView protein in InterPro
IPR016358 Hemopexin
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
PfamiView protein in Pfam
PF00045 Hemopexin, 5 hits
PIRSFiPIRSF002551 Hemopexin_chordata, 1 hit
SMARTiView protein in SMART
SM00120 HX, 5 hits
SUPFAMiSSF50923 SSF50923, 2 hits
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 2 hits
PS51642 HEMOPEXIN_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEMO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02790
Secondary accession number(s): B2R957
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: September 18, 2019
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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