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Entry version 191 (18 Sep 2019)
Sequence version 1 (01 Apr 1988)
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Protein

Gastric triacylglycerol lipase

Gene

LIPF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei172Nucleophile1 Publication1
Active sitei343Charge relay system1 Publication1
Active sitei372Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-192456 Digestion of dietary lipid

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-LIPF Acidic_Lipase

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000524

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gastric triacylglycerol lipase (EC:3.1.1.3)
Short name:
GL
Short name:
Gastric lipase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIPF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6622 LIPF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601980 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07098

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8513

Open Targets

More...
OpenTargetsi
ENSG00000182333

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30394

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1796

Drug and drug target database

More...
DrugBanki
DB01083 Orlistat
DB02457 Undecyl-Phosphinic Acid Butyl Ester

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIPF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126306

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001776620 – 398Gastric triacylglycerol lipaseAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi246 ↔ 2551 Publication
Glycosylationi271N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi327N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P07098

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07098

PeptideAtlas

More...
PeptideAtlasi
P07098

PRoteomics IDEntifications database

More...
PRIDEi
P07098

ProteomicsDB human proteome resource

More...
ProteomicsDBi
25718
51948 [P07098-1]
65595

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07098

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07098

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P07098

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182333 Expressed in 91 organ(s), highest expression level in fundus of stomach

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P07098 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045930

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114085, 10 interactors

Protein interaction database and analysis system

More...
IntActi
P07098, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377900

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P07098

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07098

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 377AB hydrolase-1Sequence analysisAdd BLAST300

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2624 Eukaryota
COG0596 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161066

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000240694

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07098

KEGG Orthology (KO)

More...
KOi
K14452

Identification of Orthologs from Complete Genome Data

More...
OMAi
GANDWMC

Database of Orthologous Groups

More...
OrthoDBi
1387662at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07098

TreeFam database of animal gene trees

More...
TreeFami
TF315485

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR039097 Gastric_lipase
IPR025483 Lipase_euk

The PANTHER Classification System

More...
PANTHERi
PTHR11005:SF15 PTHR11005:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00561 Abhydrolase_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000862 Steryl_ester_lip, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00120 LIPASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P07098-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE
60 70 80 90 100
VVTEDGYILE VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN
110 120 130 140 150
SLAFILADAG YDVWLGNSRG NTWARRNLYY SPDSVEFWAF SFDEMAKYDL
160 170 180 190 200
PATIDFIVKK TGQKQLHYVG HSQGTTIGFI AFSTNPSLAK RIKTFYALAP
210 220 230 240 250
VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF LATEVCSREM
260 270 280 290 300
LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS
310 320 330 340 350
GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD
360 370 380 390
VGLLLPKLPN LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK
Length:398
Mass (Da):45,238
Last modified:April 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD3EE1621C014F0F
GO
Isoform 2 (identifier: P07098-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-107: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):41,693
Checksum:i31199D27DA2A3863
GO
Isoform 3 (identifier: P07098-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFSNANSRSKM

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,361
Checksum:i96E2AFF12E20DF86
GO
Isoform 4 (identifier: P07098-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFSNANSRSKM
     75-107: Missing.

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):42,816
Checksum:i17FA3CD30823DDCF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA29414 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350D → N in BAH13459 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011947161T → A2 PublicationsCorresponds to variant dbSNP:rs814628Ensembl.1
Natural variantiVAR_020565224F → I1 PublicationCorresponds to variant dbSNP:rs6586145Ensembl.1
Natural variantiVAR_020566348P → T1 PublicationCorresponds to variant dbSNP:rs17333991Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472951M → MFSNANSRSKM in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_04729675 – 107Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X05997 mRNA Translation: CAA29413.1
X05997 mRNA Translation: CAA29414.1 Different initiation.
AK301310 mRNA Translation: BAH13457.1
AK301320 mRNA Translation: BAH13459.1
AK312940 mRNA Translation: BAG35782.1
AL833751 mRNA Translation: CAH56244.1
AY631869 Genomic DNA Translation: AAT38115.1
AL358532 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50162.1
BC112272 mRNA Translation: AAI12273.1
BC113711 mRNA Translation: AAI13712.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55718.1 [P07098-3]
CCDS55719.1 [P07098-2]
CCDS65896.1 [P07098-4]
CCDS7389.1 [P07098-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S07145

NCBI Reference Sequences

More...
RefSeqi
NP_001185757.1, NM_001198828.1 [P07098-2]
NP_001185758.1, NM_001198829.1 [P07098-3]
NP_001185759.1, NM_001198830.1 [P07098-4]
NP_004181.1, NM_004190.3 [P07098-1]
XP_011538613.1, XM_011540311.1 [P07098-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238983; ENSP00000238983; ENSG00000182333 [P07098-1]
ENST00000355843; ENSP00000348101; ENSG00000182333 [P07098-4]
ENST00000394375; ENSP00000377900; ENSG00000182333 [P07098-3]
ENST00000608620; ENSP00000477140; ENSG00000182333 [P07098-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8513

UCSC genome browser

More...
UCSCi
uc001kfg.3 human [P07098-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05997 mRNA Translation: CAA29413.1
X05997 mRNA Translation: CAA29414.1 Different initiation.
AK301310 mRNA Translation: BAH13457.1
AK301320 mRNA Translation: BAH13459.1
AK312940 mRNA Translation: BAG35782.1
AL833751 mRNA Translation: CAH56244.1
AY631869 Genomic DNA Translation: AAT38115.1
AL358532 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50162.1
BC112272 mRNA Translation: AAI12273.1
BC113711 mRNA Translation: AAI13712.1
CCDSiCCDS55718.1 [P07098-3]
CCDS55719.1 [P07098-2]
CCDS65896.1 [P07098-4]
CCDS7389.1 [P07098-1]
PIRiS07145
RefSeqiNP_001185757.1, NM_001198828.1 [P07098-2]
NP_001185758.1, NM_001198829.1 [P07098-3]
NP_001185759.1, NM_001198830.1 [P07098-4]
NP_004181.1, NM_004190.3 [P07098-1]
XP_011538613.1, XM_011540311.1 [P07098-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLGX-ray3.00A/B28-398[»]
SMRiP07098
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114085, 10 interactors
IntActiP07098, 8 interactors
STRINGi9606.ENSP00000377900

Chemistry databases

ChEMBLiCHEMBL1796
DrugBankiDB01083 Orlistat
DB02457 Undecyl-Phosphinic Acid Butyl Ester

DrugCentral

More...
DrugCentrali
P07098
SwissLipidsiSLP:000000524

Protein family/group databases

ESTHERihuman-LIPF Acidic_Lipase

PTM databases

iPTMnetiP07098
PhosphoSitePlusiP07098

Polymorphism and mutation databases

BioMutaiLIPF
DMDMi126306

Proteomic databases

MassIVEiP07098
PaxDbiP07098
PeptideAtlasiP07098
PRIDEiP07098
ProteomicsDBi25718
51948 [P07098-1]
65595

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8513
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238983; ENSP00000238983; ENSG00000182333 [P07098-1]
ENST00000355843; ENSP00000348101; ENSG00000182333 [P07098-4]
ENST00000394375; ENSP00000377900; ENSG00000182333 [P07098-3]
ENST00000608620; ENSP00000477140; ENSG00000182333 [P07098-2]
GeneIDi8513
KEGGihsa:8513
UCSCiuc001kfg.3 human [P07098-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8513
DisGeNETi8513

GeneCards: human genes, protein and diseases

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GeneCardsi
LIPF
HGNCiHGNC:6622 LIPF
HPAiHPA045930
MIMi601980 gene
neXtProtiNX_P07098
OpenTargetsiENSG00000182333
PharmGKBiPA30394

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2624 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00940000161066
HOGENOMiHOG000240694
InParanoidiP07098
KOiK14452
OMAiGANDWMC
OrthoDBi1387662at2759
PhylomeDBiP07098
TreeFamiTF315485

Enzyme and pathway databases

ReactomeiR-HSA-192456 Digestion of dietary lipid

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LIPF human
EvolutionaryTraceiP07098

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8513

Pharos

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Pharosi
P07098
PMAP-CutDBiP07098

Protein Ontology

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PROi
PR:P07098

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000182333 Expressed in 91 organ(s), highest expression level in fundus of stomach
GenevisibleiP07098 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR039097 Gastric_lipase
IPR025483 Lipase_euk
PANTHERiPTHR11005:SF15 PTHR11005:SF15, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000862 Steryl_ester_lip, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07098
Secondary accession number(s): B7Z723
, F5H1P4, Q2M1P6, Q5VXI7, Q5VXI8, Q658L8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 18, 2019
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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