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Entry version 195 (16 Oct 2019)
Sequence version 4 (06 Dec 2005)
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Protein

Collagen alpha-1(I) chain

Gene

Col1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1266CalciumBy similarity1
Metal bindingi1268CalciumBy similarity1
Metal bindingi1269Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1271Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1274CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114604 GPVI-mediated activation cascade
R-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(I) chain
Alternative name(s):
Alpha-1 type I collagen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col1a1
Synonyms:Cola1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88467 Col1a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000572223 – 151N-terminal propeptideAdd BLAST129
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000005723152 – 1207Collagen alpha-1(I) chainAdd BLAST1056
PropeptideiPRO_00000057241208 – 1453C-terminal propeptideAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160AllysineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei1794-hydroxyprolineBy similarity1
Modified residuei1824-hydroxyprolineBy similarity1
Modified residuei1854-hydroxyprolineBy similarity1
Modified residuei1944-hydroxyprolineBy similarity1
Modified residuei1974-hydroxyprolineBy similarity1
Modified residuei2004-hydroxyprolineBy similarity1
Modified residuei2154-hydroxyprolineBy similarity1
Modified residuei2304-hydroxyprolineBy similarity1
Modified residuei2364-hydroxyprolineBy similarity1
Modified residuei2454-hydroxyprolineBy similarity1
Modified residuei2514-hydroxyprolineBy similarity1
Modified residuei2545-hydroxylysine; alternate1 Publication1
Glycosylationi254O-linked (Gal...) hydroxylysine; alternate1 Publication1
Modified residuei260PhosphoserineBy similarity1
Modified residuei2784-hydroxyprolineBy similarity1
Modified residuei2814-hydroxyprolineBy similarity1
Modified residuei2874-hydroxyprolineBy similarity1
Modified residuei2964-hydroxyprolineBy similarity1
Modified residuei3024-hydroxyprolineBy similarity1
Modified residuei3234-hydroxyprolineBy similarity1
Modified residuei3324-hydroxyprolineBy similarity1
Modified residuei3354-hydroxyprolineBy similarity1
Modified residuei3624-hydroxyprolineBy similarity1
Modified residuei3654-hydroxyprolineBy similarity1
Modified residuei3774-hydroxyprolineBy similarity1
Modified residuei3834-hydroxyprolineBy similarity1
Modified residuei3924-hydroxyprolineBy similarity1
Modified residuei3984-hydroxyprolineBy similarity1
Modified residuei4014-hydroxyprolineBy similarity1
Modified residuei4164-hydroxyprolineBy similarity1
Modified residuei4195-hydroxylysineBy similarity1
Modified residuei4254-hydroxyprolineBy similarity1
Modified residuei4284-hydroxyprolineBy similarity1
Modified residuei4404-hydroxyprolineBy similarity1
Modified residuei4494-hydroxyprolineBy similarity1
Modified residuei4644-hydroxyprolineBy similarity1
Modified residuei4704-hydroxyprolineBy similarity1
Modified residuei4794-hydroxyprolineBy similarity1
Modified residuei4854-hydroxyprolineBy similarity1
Modified residuei4945-hydroxylysineBy similarity1
Modified residuei5034-hydroxyprolineBy similarity1
Modified residuei5124-hydroxyprolineBy similarity1
Modified residuei5184-hydroxyprolineBy similarity1
Modified residuei5244-hydroxyprolineBy similarity1
Modified residuei5334-hydroxyprolineBy similarity1
Modified residuei5364-hydroxyprolineBy similarity1
Modified residuei5454-hydroxyprolineBy similarity1
Modified residuei5544-hydroxyprolineBy similarity1
Modified residuei5604-hydroxyprolineBy similarity1
Modified residuei5724-hydroxyprolineBy similarity1
Modified residuei5814-hydroxyprolineBy similarity1
Modified residuei5904-hydroxyprolineBy similarity1
Modified residuei5934-hydroxyprolineBy similarity1
Modified residuei6114-hydroxyprolineBy similarity1
Modified residuei6294-hydroxyprolineBy similarity1
Modified residuei6354-hydroxyprolineBy similarity1
Modified residuei6414-hydroxyprolineBy similarity1
Modified residuei6474-hydroxyprolineBy similarity1
Modified residuei6534-hydroxyprolineBy similarity1
Modified residuei6594-hydroxyprolineBy similarity1
Modified residuei6714-hydroxyprolineBy similarity1
Modified residuei6804-hydroxyprolineBy similarity1
Modified residuei6924-hydroxyprolineBy similarity1
Modified residuei7044-hydroxyprolineBy similarity1
Modified residuei7074-hydroxyprolineBy similarity1
Modified residuei7134-hydroxyprolineBy similarity1
Modified residuei7194-hydroxyprolineBy similarity1
Modified residuei7284-hydroxyprolineBy similarity1
Modified residuei7405-hydroxylysineBy similarity1
Modified residuei7464-hydroxyprolineBy similarity1
Modified residuei7614-hydroxyprolineBy similarity1
Modified residuei7674-hydroxyprolineBy similarity1
Modified residuei776PhosphoserineBy similarity1
Modified residuei7884-hydroxyprolineBy similarity1
Modified residuei7974-hydroxyprolineBy similarity1
Modified residuei8064-hydroxyprolineBy similarity1
Modified residuei8124-hydroxyprolineBy similarity1
Modified residuei8304-hydroxyprolineBy similarity1
Modified residuei8394-hydroxyprolineBy similarity1
Modified residuei8484-hydroxyprolineBy similarity1
Modified residuei8515-hydroxylysineBy similarity1
Modified residuei8604-hydroxyprolineBy similarity1
Modified residuei8664-hydroxyprolineBy similarity1
Modified residuei8743-hydroxyproline1 Publication1
Modified residuei8754-hydroxyproline1 Publication1
Modified residuei8844-hydroxyproline1 Publication1
Modified residuei8874-hydroxyproline1 Publication1
Modified residuei9084-hydroxyprolineBy similarity1
Modified residuei9174-hydroxyprolineBy similarity1
Modified residuei9264-hydroxyprolineBy similarity1
Modified residuei9354-hydroxyprolineBy similarity1
Modified residuei9534-hydroxyprolineBy similarity1
Modified residuei9624-hydroxyprolineBy similarity1
Modified residuei9654-hydroxyprolineBy similarity1
Modified residuei9714-hydroxyprolineBy similarity1
Modified residuei9864-hydroxyprolineBy similarity1
Modified residuei9924-hydroxyprolineBy similarity1
Modified residuei9984-hydroxyprolineBy similarity1
Modified residuei10074-hydroxyprolineBy similarity1
Modified residuei10134-hydroxyprolineBy similarity1
Modified residuei10225-hydroxylysineBy similarity1
Modified residuei10344-hydroxyprolineBy similarity1
Modified residuei10374-hydroxyprolineBy similarity1
Modified residuei10404-hydroxyprolineBy similarity1
Modified residuei10855-hydroxylysineBy similarity1
Modified residuei10975-hydroxylysine; alternate1 Publication1
Glycosylationi1097O-linked (Gal...) hydroxylysine; alternate1 Publication1
Modified residuei11094-hydroxyprolineBy similarity1
Modified residuei11124-hydroxyprolineBy similarity1
Modified residuei11154-hydroxyprolineBy similarity1
Modified residuei11334-hydroxyprolineBy similarity1
Modified residuei11484-hydroxyproline1 Publication1
Modified residuei11533-hydroxyproline1 Publication1
Modified residuei11544-hydroxyproline1 Publication1
Modified residuei11683-hydroxyproline1 Publication1
Modified residuei11694-hydroxyproline1 Publication1
Modified residuei11713-hydroxyproline1 Publication1
Modified residuei11724-hydroxyproline1 Publication1
Modified residuei11743-hydroxyproline1 Publication1
Modified residuei11754-hydroxyproline1 Publication1
Modified residuei11784-hydroxyproline1 Publication1
Modified residuei11814-hydroxyproline1 Publication1
Modified residuei1197AllysineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1248 ↔ 1280PROSITE-ProRule annotation
Disulfide bondi1254Interchain (with C-1271)PROSITE-ProRule annotation
Disulfide bondi1271Interchain (with C-1254)PROSITE-ProRule annotation
Disulfide bondi1288 ↔ 1451PROSITE-ProRule annotation
Glycosylationi1354N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1359 ↔ 1404PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.1 Publication
Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.1 Publication
Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains.1 Publication1 Publication
O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3568

Encyclopedia of Proteome Dynamics

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EPDi
P11087

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P11087

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11087

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11087

PeptideAtlas

More...
PeptideAtlasi
P11087

PRoteomics IDEntifications database

More...
PRIDEi
P11087

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2220

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11087

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11087

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P11087

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001506 Expressed in 288 organ(s), highest expression level in cochlea

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11087 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers of one alpha 2(I) and two alpha 1(I) chains.

Interacts with MRC2.

Interacts with TRAM2.

Interacts with MFAP4 in a Ca (2+)-dependent manner.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198831, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2956 Collagen type I trimer

Protein interaction database and analysis system

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IntActi
P11087, 2 interactors

Molecular INTeraction database

More...
MINTi
P11087

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000001547

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11087

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 87VWFCPROSITE-ProRule annotationAdd BLAST59
Domaini1218 – 1453Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 167Nonhelical region (N-terminal)Add BLAST16
Regioni168 – 1181Triple-helical regionAdd BLAST1014
Regioni1182 – 1207Nonhelical region (C-terminal)Add BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi734 – 736Cell attachment siteSequence analysis3
Motifi1082 – 1084Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156584

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11087

KEGG Orthology (KO)

More...
KOi
K06236

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDSGTWV

Database of Orthologous Groups

More...
OrthoDBi
337699at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11087

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 9 hits
PF00093 VWC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P11087-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSFVDLRLL LLLGATALLT HGQEDIPEVS CIHNGLRVPN GETWKPEVCL
60 70 80 90 100
ICICHNGTAV CDDVQCNEEL DCPNPQRREG ECCAFCPEEY VSPNSEDVGV
110 120 130 140 150
EGPKGDPGPQ GPRGPVGPPG RDGIPGQPGL PGPPGPPGPP GPPGLGGNFA
160 170 180 190 200
SQMSYGYDEK SAGVSVPGPM GPSGPRGLPG PPGAPGPQGF QGPPGEPGEP
210 220 230 240 250
GGSGPMGPRG PPGPPGKNGD DGEAGKPGRP GERGPPGPQG ARGLPGTAGL
260 270 280 290 300
PGMKGHRGFS GLDGAKGDAG PAGPKGEPGS PGENGAPGQM GPRGLPGERG
310 320 330 340 350
RPGPPGTAGA RGNDGAVGAA GPPGPTGPTG PPGFPGAVGA KGEAGPQGAR
360 370 380 390 400
GSEGPQGVRG EPGPPGPAGA AGPAGNPGAD GQPGAKGANG APGIAGAPGF
410 420 430 440 450
PGARGPSGPQ GPSGPPGPKG NSGEPGAPGN KGDTGAKGEP GATGVQGPPG
460 470 480 490 500
PAGEEGKRGA RGEPGPSGLP GPPGERGGPG SRGFPGADGV AGPKGPSGER
510 520 530 540 550
GAPGPAGPKG SPGEAGRPGE AGLPGAKGLT GSPGSPGPDG KTGPPGPAGQ
560 570 580 590 600
DGRPGPAGPP GARGQAGVMG FPGPKGTAGE PGKAGERGLP GPPGAVGPAG
610 620 630 640 650
KDGEAGAQGA PGPAGPAGER GEQGPAGSPG FQGLPGPAGP PGEAGKPGEQ
660 670 680 690 700
GVPGDLGAPG PSGARGERGF PGERGVQGPP GPAGPRGNNG APGNDGAKGD
710 720 730 740 750
TGAPGAPGSQ GAPGLQGMPG ERGAAGLPGP KGDRGDAGPK GADGSPGKDG
760 770 780 790 800
ARGLTGPIGP PGPAGAPGDK GEAGPSGPPG PTGARGAPGD RGEAGPPGPA
810 820 830 840 850
GFAGPPGADG QPGAKGEPGD TGVKGDAGPP GPAGPAGPPG PIGNVGAPGP
860 870 880 890 900
KGPRGAAGPP GATGFPGAAG RVGPPGPSGN AGPPGPPGPV GKEGGKGPRG
910 920 930 940 950
ETGPAGRPGE VGPPGPPGPA GEKGSPGADG PAGSPGTPGP QGIAGQRGVV
960 970 980 990 1000
GLPGQRGERG FPGLPGPSGE PGKQGPSGSS GERGPPGPMG PPGLAGPPGE
1010 1020 1030 1040 1050
SGREGSPGAE GSPGRDGAPG AKGDRGETGP AGPPGAPGAP GAPGPVGPAG
1060 1070 1080 1090 1100
KNGDRGETGP AGPAGPIGPA GARGPAGPQG PRGDKGETGE QGDRGIKGHR
1110 1120 1130 1140 1150
GFSGLQGPPG SPGSPGEQGP SGASGPAGPR GPPGSAGSPG KDGLNGLPGP
1160 1170 1180 1190 1200
IGPPGPRGRT GDSGPAGPPG PPGPPGPPGP PSGGYDFSFL PQPPQEKSQD
1210 1220 1230 1240 1250
GGRYYRADDA NVVRDRDLEV DTTLKSLSQQ IENIRSPEGS RKNPARTCRD
1260 1270 1280 1290 1300
LKMCHSDWKS GEYWIDPNQG CNLDAIKVYC NMETGQTCVF PTQPSVPQKN
1310 1320 1330 1340 1350
WYISPNPKEK KHVWFGESMT DGFPFEYGSE GSDPADVAIQ LTFLRLMSTE
1360 1370 1380 1390 1400
ASQNITYHCK NSVAYMDQQT GNLKKALLLQ GSNEIELRGE GNSRFTYSTL
1410 1420 1430 1440 1450
VDGCTSHTGT WGKTVIEYKT TKTSRLPIID VAPLDIGAPD QEFGLDIGPA

CFV
Length:1,453
Mass (Da):138,032
Last modified:December 6, 2005 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B7F06BBB9A1D5EA
GO
Isoform 2 (identifier: P11087-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     803-1030: Missing.

Note: No experimental confirmation available.
Show »
Length:1,225
Mass (Da):117,820
Checksum:i5EBF34F79AD32E86
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA38657 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81E → G in AAA88912 (PubMed:8535610).Curated1
Sequence conflicti106D → G in AAA88912 (PubMed:8535610).Curated1
Sequence conflicti136P → H in AAH59281 (PubMed:15489334).Curated1
Sequence conflicti1202G → D in AAA88912 (PubMed:8535610).Curated1
Sequence conflicti1219E → A in AAA88912 (PubMed:8535610).Curated1
Sequence conflicti1222T → A in AAA88912 (PubMed:8535610).Curated1
Sequence conflicti1335A → T in AAA88912 (PubMed:8535610).Curated1
Sequence conflicti1399 – 1400TL → RV in AAA88912 (PubMed:8535610).Curated2
Sequence conflicti1450A → V in CAA29927 (PubMed:3340560).Curated1
Sequence conflicti1450A → V in CAA33904 (PubMed:3340560).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016548803 – 1030Missing in isoform 2. 1 PublicationAdd BLAST228

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U08020 mRNA Translation: AAA88912.1
AL606480 Genomic DNA No translation available.
AL662790 Genomic DNA No translation available.
BC050014 mRNA Translation: AAH50014.1
BC059281 mRNA Translation: AAH59281.1
K01688 Genomic DNA Translation: AAA37330.1
S67530 Genomic DNA Translation: AAB29424.1
S67482 Genomic DNA No translation available.
X54876 Genomic DNA Translation: CAA38657.1 Sequence problems.
M14423 mRNA Translation: AAA37333.1
M17491 Genomic DNA Translation: AAA37334.1
K03036
, K03029, K03030, K03031, K03032, K03033, K03034, K03035 Genomic DNA Translation: AAA37332.1
X06753 Genomic DNA Translation: CAA29927.1
X15896 Genomic DNA Translation: CAA33904.1
X57981 Genomic DNA Translation: CAA41046.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25265.1 [P11087-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I49558
S57243 S21626

NCBI Reference Sequences

More...
RefSeqi
NP_031768.2, NM_007742.4 [P11087-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000001547; ENSMUSP00000001547; ENSMUSG00000001506 [P11087-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12842

UCSC genome browser

More...
UCSCi
uc007kzn.1 mouse [P11087-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08020 mRNA Translation: AAA88912.1
AL606480 Genomic DNA No translation available.
AL662790 Genomic DNA No translation available.
BC050014 mRNA Translation: AAH50014.1
BC059281 mRNA Translation: AAH59281.1
K01688 Genomic DNA Translation: AAA37330.1
S67530 Genomic DNA Translation: AAB29424.1
S67482 Genomic DNA No translation available.
X54876 Genomic DNA Translation: CAA38657.1 Sequence problems.
M14423 mRNA Translation: AAA37333.1
M17491 Genomic DNA Translation: AAA37334.1
K03036
, K03029, K03030, K03031, K03032, K03033, K03034, K03035 Genomic DNA Translation: AAA37332.1
X06753 Genomic DNA Translation: CAA29927.1
X15896 Genomic DNA Translation: CAA33904.1
X57981 Genomic DNA Translation: CAA41046.1
CCDSiCCDS25265.1 [P11087-1]
PIRiI49558
S57243 S21626
RefSeqiNP_031768.2, NM_007742.4 [P11087-1]

3D structure databases

SMRiP11087
ModBaseiSearch...

Protein-protein interaction databases

BioGridi198831, 9 interactors
ComplexPortaliCPX-2956 Collagen type I trimer
IntActiP11087, 2 interactors
MINTiP11087
STRINGi10090.ENSMUSP00000001547

PTM databases

GlyConnecti2220
iPTMnetiP11087
PhosphoSitePlusiP11087

Proteomic databases

CPTACinon-CPTAC-3568
EPDiP11087
jPOSTiP11087
MaxQBiP11087
PaxDbiP11087
PeptideAtlasiP11087
PRIDEiP11087

Genome annotation databases

EnsembliENSMUST00000001547; ENSMUSP00000001547; ENSMUSG00000001506 [P11087-1]
GeneIDi12842
KEGGimmu:12842
UCSCiuc007kzn.1 mouse [P11087-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1277
MGIiMGI:88467 Col1a1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000156584
InParanoidiP11087
KOiK06236
OMAiNDSGTWV
OrthoDBi337699at2759
PhylomeDBiP11087
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Col1a1 mouse
PMAP-CutDBiP11087

Protein Ontology

More...
PROi
PR:P11087

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001506 Expressed in 288 organ(s), highest expression level in cochlea
GenevisibleiP11087 MM

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 9 hits
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO1A1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11087
Secondary accession number(s): Q53WT0
, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 6, 2005
Last modified: October 16, 2019
This is version 195 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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